This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Suppression of All Three Major Lymphocyte Subsets

Richard B. Tenser, MD; Kathleen A. Hay, PhD; Judith A. Aberg, MD

Arch Neurol. 1993;50(4):417-420.

Abstract
• Six patients with relapsing chronic progressive multiple sclerosis were treated on 2 consecutive days with large amounts of IgG to induce immunosuppression. Peripheral blood lymphocyte subsets were monitored for 5 weeks after IgG treatment to determine immunosuppression. Decreased numbers of B, T, and natural killer lymphocytes were detected after treatment. Lymphocyte numbers were at a nadir 1 week after treatment, but an immunosuppressive effect continued to be present after 5 weeks. Although clinical efficacy was not evident in this brief open trial, the decrease of peripheral lymphocyte numbers and the apparent safety of the procedure warrant further study.

Author Affiliations
From the Division of Neurology, Penn State University College of Medicine, Hershey, Pa. Dr Aberg is now with the Cleveland (Ohio) Clinic Foundation.

Footnotes
Accepted for publication November 2, 1992.

Reprint requests to Division of Neurology, PO Box 850, Hershey, PA 17033 (Dr Tenser).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

IV immunoglobulin reduces circulating proinflammatory cytokines in Guillain-Barre syndrome
Sharief et al.
Neurology 1999;52:1833-1833.
ABSTRACT | FULL TEXT  

Immunomodulation and remyelination: two aspects of human polyclonal immunoglobulin treatment in immune mediated neuropathies?
van Schaik et al.
Mult Scler 1997;3:98-104.
ABSTRACT  

Treatment effects of monthly intravenous immunoglobulin on patients with relapsing - remitting Multiple Sclerosis: Further analyses of the Austrian immunoglobulin in MS Study
Fazekas et al.
Mult Scler 1997;3:137-141.
ABSTRACT  

A double-blind, cross-over trial of intravenous immunoglobulin G in multiple sclerosis: Preliminary results
Sorensen et al.
Mult Scler 1997;3:145-148.
ABSTRACT  

Intravenous immunoglobulin G therapy: effects of acute and chronic treatment in multiple sclerosis
Sorensen
Mult Scler 1996;1:349-352.
ABSTRACT