This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Bernard Pillon, PhD; Bernard Deweer, PhD; Yves Agid, MD, PhD; Bruno Dubois, MD

Arch Neurol. 1993;50(4):374-379.

Abstract
• Objective.
—Comparing the pattern of spared and impaired memory functions in neurodegenerative diseases known to affect different brain structures.

Design.
—Various situations of acquisition (free encoding or controlled encoding) and retrieval (immediate and delayed free and cued recall, recognition) were used.

Setting.
—Referral center.

Patients.
—Fifteen for each disease (ie, senile dementia of the Alzheimer type [SDAT], Parkinson's, and Huntington's), matched for education, severity of dementia, and depression.

Main Outcome Measures.
—Comparison of free and controlled encoding situations, relationships between memory, executive, and linguistic functions test scores.

Results.
—In the free encoding situation: no difference among the three groups, but higher numbers of intrusions and false recognitions in SDAT. In the controlled situation: cued recall and recognition scores significantly higher in Parkinson's disease and Huntington's disease than in SDAT. Memory performances correlated with executive functions test scores in Huntington's disease and Parkinson's disease, but not in SDAT. All results significant at P<.01.

Conclusions.
—Clear distinction between the true amnesic syndrome of SDAT, compatible with lesions of hippocampus and temporal cortex, and the inefficient planning of memory processes of Huntington's disease and Parkinson's disease, which might result from a striatofrontal dysfunction.

Author Affiliations
From the Neurology and Neuropsychology Service, Hôpital de la SalSal-Paris, France.

Footnotes
Accepted for publication September 24, 1992.

Reprint requests to Inserm U 289 and Service de Neurologie et Neuropsychologie, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France (Dr Pillon).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy
Benedict et al.
J. Neurol. Neurosurg. Psychiatry 2009;80:201-206.
ABSTRACT | FULL TEXT  

Evidence of persisting cognitive impairment in a case series of patients with locked-in syndrome
Rousseaux et al.
J. Neurol. Neurosurg. Psychiatry 2009;80:166-170.
ABSTRACT | FULL TEXT  

Evolution of cognitive dysfunction in an incident Parkinson's disease cohort
Williams-Gray et al.
Brain 2007;130:1787-1798.
ABSTRACT | FULL TEXT  

Exploring the recognition memory deficit in Parkinson's disease: estimates of recollection versus familiarity
Davidson et al.
Brain 2006;129:1768-1779.
ABSTRACT | FULL TEXT  

Cognitive Predictors of Dementia in Parkinson's Disease: A Community-Based, 4-Year Longitudinal Study
Janvin et al.
J Geriatr Psychiatry Neurol 2005;18:149-154.
ABSTRACT  

A syndromal analysis of neuropsychological outcome following coronary artery bypass graft surgery
Kneebone et al.
J. Neurol. Neurosurg. Psychiatry 2005;76:1121-1127.
ABSTRACT | FULL TEXT  

Alzheimer's Disease
Cummings
NEJM 2004;351:56-67.
FULL TEXT  

Assessment of cognition in Parkinson's disease
Marinus et al.
Neurology 2003;61:1222-1228.
ABSTRACT | FULL TEXT  

Is normal pressure hydrocephalus a valid concept in 2002? A reappraisal in five questions and proposal for a new designation of the syndrome as "chronic hydrocephalus"
Bret et al.
J. Neurol. Neurosurg. Psychiatry 2002;73:9-12.
ABSTRACT | FULL TEXT  

Subcortical dementia
TURNER et al.
Br. J. Psychiatry 2002;180:148-151.
ABSTRACT | FULL TEXT  

Prefrontal regions supporting spontaneous and directed application of verbal learning strategies: Evidence from PET
Savage et al.
Brain 2001;124:219-231.
ABSTRACT | FULL TEXT  

Cognitive Impairment and the Brain Dopaminergic System in Parkinson Disease: [18F]Fluorodopa Positron Emission Tomographic Study
Rinne et al.
Arch Neurol 2000;57:470-475.
ABSTRACT | FULL TEXT  

Testing memory for self-generated items in dementia: Method makes a difference
Barrett et al.
Neurology 2000;54:1258-1264.
ABSTRACT | FULL TEXT  

Are cognitive changes the first symptoms of Huntington's disease? A study of gene carriers
Hahn-Barma et al.
J. Neurol. Neurosurg. Psychiatry 1998;64:172-177.
ABSTRACT | FULL TEXT  

Implicit and Explicit Memory in Patients With Parkinson's Disease With and Without Dementia
Appollonio et al.
Arch Neurol 1994;51:359-367.
ABSTRACT