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Terry L. Jernigan, PhD; Sarah Archibald, MA; John R. Hesselink, MD; J. Hampton Atkinson, MD; Robert A. Velin, PhD; J. Allen McCutchan, MD; James Chandler, MD; Igor Grant, MD; HNRC Group

Arch Neurol. 1993;50(3):250-255.

Abstract
• Magnetic resonance imaging was used to compare male subjects seropositive for antibody to human immunodeficiency virus type 1 (HIV positive), with and without medical symptoms, with two groups of men who were seronegative (HIV negative). The control subjects included men at high risk for exposure to HIV-1 and those at low risk. None of the HIV-positive subjects met criteria for HIV-associated dementia or had detectable opportunistic brain disease. Quantitative image-analytic techniques were used to estimate volumes of ventricular and cortical cerebrospinal fluid, cerebral white matter, and cortical and subcortical gray matter structures. Relative to low-risk group control subjects and asymptomatic HIV-positive subjects, nondemented but medically symptomatic HIV-positive subjects showed significant increases in cerebrospinal fluid, reduced volume of cerebral white matter, and reduced cerebral gray matter volumes. Unexpectedly, however, some cerebrospinal fluid increases and gray matter volume decreases were present in the seronegative high-risk control subjects as well.

Author Affiliations
From the San Diego Department of Veterans Affairs Medical Center (Drs Jernigan, Hesselink, Atkinson, and Grant); the University of California, San Diego, School of Medicine (Drs Jernigan, Hesselink, Atkinson, Velin, McCutchan, and Grant, and Ms Archibald); and the Naval Hospital (Dr Chandler), San Diego, Calif.

Footnotes
Accepted for publication August 24, 1992.

The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government.

Reprint requests to Department of Psychiatry, 0631-P, University of California—San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0631 (Dr Jernigan).

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