Memory evaluation in Alzheimer's disease. Caregivers' appraisals and objective testing
E. Koss, M. B. Patterson, R. Ownby, J. C. Stuckey and P. J. Whitehouse
Department of Neurology, Case Western Reserve University, Cleveland, OH.
OBJECTIVES--To evaluate if caregivers are reliable informants concerning
memory deficits in patients with Alzheimer's disease (AD).
DESIGN--Responses of caregivers of patients with probable AD and responses
of healthy control subjects on a standardized memory questionnaire were
compared with objective measures of cognition (Consortium to Establish a
Registry for Alzheimer's Disease neuropsychological battery) and with
clinical estimates of activities of daily living, depression, and
psychopathology (Consortium to Establish a Registry for Alzheimer's Disease
[CERAD] clinical assessment battery) using the Self-report Memory
Questionnaire. SETTING--A federally funded AD research center.
SUBJECTS--The referred sample included 117 patients with probable AD, their
informants, and 41 healthy control subjects age-matched to the patients.
Patients and control subjects were between the ages of 58 and 85 years, had
between 9 and 19 years of education, and were in good health.
EXCLUSIONS--Patients who did not meet NINCDS-ADRDA criteria of probable AD.
MAIN OUTCOME MEASURE--The optimal number of questionnaire items yielding
the best combination of sensitivity and specificity. RESULTS--An
abbreviated version of the scale, renamed the Short-Memory Questionnaire,
had excellent specificity and sensitivity for identifying dementia.
Positive and negative predictive values were 63.5% and near 100%,
respectively. The Short-Memory Questionnaire showed good reliability,
internal consistency, and external validity. Caregiver appraisals of memory
deficits significantly correlated with objective measures of memory and
also with generalized cognitive dysfunction. CONCLUSIONS--Caregivers of
patients with AD are reliable informants of their relatives' deficits. The
Short-Memory Questionnaire is an easily administered, informant-based scale
that may be useful in clinical settings or epidemiologic studies to screen
out persons with memory difficulties.
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