Neuropsychiatric correlates of cerebral white-matter radiolucencies in probable Alzheimer's disease
O. L. Lopez, J. T. Becker, D. Rezek, J. Wess, F. Boller, C. F. Reynolds 3rd and M. Panisset
Department of Neurology, Alzheimer's Disease Research Center, University of Pittsburgh, School of Medicine, PA 15213.
We evaluated the neuropsychological functions, rate of disease progression,
and psychiatric characteristics of 22 patients with probable Alzheimer's
disease in whom periventricular white-matter radiolucencies (PWMRs) were
seen on the computed tomographic scan of the brain and compared them with
22 matched patients with Alzheimer's disease without PWMRs.
Executive/attention, lexical/semantic, memory/learning, and visuospatial
functions did not differ between the two groups at baseline or at the
1-year follow-up examination. The frequency of major depression, delusions,
and hallucinations did not differ between the groups. However, patients
with PWMRs had significantly higher Hachinski Rating scores at both visits
and were more likely to develop cerebrovascular disease during follow-up
than were controls with Alzheimer's disease. These preliminary results
suggest that the presence of PWMRs is not associated with specific
cognitive and psychiatric features or with an altered rate of progression
of Alzheimer's disease but does predict the development of clinically
significant cerebrovascular disease.
White matter changes in dementia: does radiology matter?
BRONGE and WAHLUND
Br. J. Radiol. 2007;80:S115-S120.
ABSTRACT
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White Matter Changes Associated With Psychotic Symptoms in Alzheimer's Disease Patients
Lee et al.
J. Neuropsychiatry Clin. Neurosi. 2006;18:191-198.
ABSTRACT
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Contribution of cerebral amyloid angiopathy to Alzheimer's disease
Love
J. Neurol. Neurosurg. Psychiatry 2004;75:1-4.
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Neuropsychiatric Significance of Subcortical Hyperintensity
Campbell and Coffey
J. Neuropsychiatry Clin. Neurosi. 2001;13:261-288.
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Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades: I
Lopez et al.
Neurology 2000;55:1854-1862.
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Impact of White Matter Changes on Clinical Manifestation of Alzheimer's Disease : A Quantitative Study
Hirono et al.
Stroke 2000;31:2182-2188.
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Neuropsychological, psychiatric, and cerebral perfusion correlates of leukoaraiosis in Alzheimer's disease
Starkstein et al.
J. Neurol. Neurosurg. Psychiatry 1997;63:66-73.
ABSTRACT
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Magnetic Resonance Imaging in the Congenital Adrenal Hyperplasia Population: Increased Frequency of White-Matter Abnormalities and Temporal Lobe Atrophy
Nass et al.
J Child Neurol 1997;12:181-186.
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The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger's Report : A Review
Pantoni and Garcia
Stroke 1995;26:1293-1301.
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