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Daniel H. Jacobs, MD; Frederick F. Holmes, MD; Michael J. McFarlane, MD

Arch Neurol. 1992;49(7):753-756.

Abstract
• We studied 283 meningiomas seen at the University of Kansas, Kansas City, from 1948 through 1984, identifying all additional nonmeningeal malignancies and primary brain tumors in these patients and calculating the expected number of additional tumors by the use of a person-year method from age and sex-matched cancer incidence data. We determined expected numbers of total neoplasms in our meningioma population as well as the expected numbers in each major organ system for the sexes independently and together. We then calculated standard morbidity ratios and 95% confidence intervals for each tumor type. The number of breast cancers did not reach statistical significance. We found a significantly increased number of second primary brain tumors in women (standard morbidity ratio, 8.0; 95% confidence interval, 2.2 to 20.4) and an increased number of thyroid cancers in both sexes (standard morbidity ratio, 7.5; 95% confidence interval, 1.5 to 21.9).

Author Affiliations
From the Departments of Neurology (Dr Jacobs) and Medicine (Dr Holmes), University of Kansas School of Medicine Kansas City; and Department of Medicine, Case Western Reserve University, Cleveland, Ohio (Dr McFarlane).

Footnotes
Accepted for publication February 21, 1992.

Reprint requests to University of Kansas School of Medicine, 39th and Rainbow streets, Kansas City, KS 66103 (Dr Holmes).

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