This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Marc I. Chimowitz, MD; Melinda L. Estes, MD; Anthony J. Furlan, MD; Issam A. Awad, MD

Arch Neurol. 1992;49(7):747-752.

Abstract
• We performed postmortem magnetic resonance imaging and pathologic examinations on the brains of seven consecutive patients older than 50 years of age who died of nonneurologic causes. Multiple hyperintense subcortical lesions were identified in each patient, and a total of 29 lesions were examined histologically (eight rims, six caps, six punctate lesions, and nine patches). Rims were characterized by subependymal gliosis and loss of the ependymal lining; caps were associated with myelin pallor, gliosis, and arteriosclerosis; punctate lesions were characterized by dilated perivascular spaces and perivascular gliosis; and patches were associated with myelin pallor and dilated perivascular spaces. The pattern of myelin pallor defined the size and shape of caps and patches. Arteriosclerosis was identified in six of six caps, three of six punctate lesions, and in three of nine patches. These data indicate that (1) each type of hyperintense subcortical lesion has a distinct pathologic correlate; (2) arteriosclerosis is not invariably associated with all types of hyperintense subcortical lesions on magnetic resonance imaging; and (3) myelin pallor appears to contribute to the magnetic resonance imaging signal at 1.5 tesla.

Author Affiliations
From the Department of Neurology, University of Michigan Medical Center, Ann Arbor (Dr Chimowitz), and Departments of Pathology (Dr Estes), Neurology (Dr Furlan), and Neurosurgery (Dr Awad), Cleveland (Ohio) Clinic Foundation.

Footnotes
Accepted for publication February 10, 1992.

Reprint requests to Department of Neurology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195 (Dr Furlan).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Neuropathologic correlates of white matter hyperintensities
Young et al.
Neurology 2008;71:804-811.
ABSTRACT | FULL TEXT  

Selective Reduction of Blood Flow to White Matter During Hypercapnia Corresponds With Leukoaraiosis
Mandell et al.
Stroke 2008;39:1993-1998.
ABSTRACT | FULL TEXT  

Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions
Bokura et al.
Stroke 2008;39:1607-1609.
ABSTRACT | FULL TEXT  

Chronic Kidney Disease Is Associated With White Matter Hyperintensity Volume: The Northern Manhattan Study (NOMAS)
Khatri et al.
Stroke 2007;38:3121-3126.
ABSTRACT | FULL TEXT  

Fiber Connections between the Cerebral Cortex and the Corpus Callosum in Alzheimer's Disease: A Diffusion Tensor Imaging and Voxel-Based Morphometry Study
Sydykova et al.
Cereb Cortex 2007;17:2276-2282.
ABSTRACT | FULL TEXT  

Comparison of MRI Sequences to Detect Ventriculitis
Fujikawa et al.
Am. J. Roentgenol. 2006;187:1048-1053.
ABSTRACT | FULL TEXT  

Genome-Wide Scan for White Matter Hyperintensity: The Framingham Heart Study
DeStefano et al.
Stroke 2006;37:77-81.
ABSTRACT | FULL TEXT  

Anatomical Mapping of White Matter Hyperintensities (WMH): Exploring the Relationships Between Periventricular WMH, Deep WMH, and Total WMH Burden
DeCarli et al.
Stroke 2005;36:50-55.
ABSTRACT | FULL TEXT  

Correlation of NO Metabolites and 8-Iso-Prostaglandin F2a With Periventricular Hyperintensity Severity
Shibata et al.
Arterioscler. Thromb. Vasc. Bio. 2004;24:1659-1663.
ABSTRACT | FULL TEXT  

Thalamic Lesions in Vascular Dementia: Low Sensitivity of Fluid-Attenuated Inversion Recovery (FLAIR) Imaging
Bastos Leite et al.
Stroke 2004;35:415-419.
ABSTRACT | FULL TEXT  

Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Chobanian et al.
Hypertension 2003;42:1206-1252.
ABSTRACT | FULL TEXT  

Ischemic Basis for Deep White Matter Hyperintensities in Major Depression: A Neuropathological Study
Thomas et al.
Arch Gen Psychiatry 2002;59:785-792.
ABSTRACT | FULL TEXT  

The neuropathology of primary mood disorder
Harrison
Brain 2002;125:1428-1449.
ABSTRACT | FULL TEXT  

Cerebral metabolic impairment in patients with obstructive sleep apnoea: an independent association of obstructive sleep apnoea with white matter change
Kamba et al.
J. Neurol. Neurosurg. Psychiatry 2001;71:334-339.
ABSTRACT | FULL TEXT  

Leukoaraiosis: Reifying Rarefaction
Merino and Hachinski
Arch Neurol 2000;57:925-926.
FULL TEXT  

Neuroanatomic Substrates of Late-Life Mental Disorders
Narayan et al.
J Geriatr Psychiatry Neurol 1999;12:95-106.
ABSTRACT  

Small Chronic Hemorrhages and Ischemic Lesions in Association With Spontaneous Intracerebral Hematomas
Tanaka et al.
Stroke 1999;30:1637-1642.
ABSTRACT | FULL TEXT  

White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging
Barber et al.
J. Neurol. Neurosurg. Psychiatry 1999;67:66-72.
ABSTRACT | FULL TEXT  

Hyperintensities of the Optic Radiation on T2-Weighted MR Images of Elderly Subjects
Kitajima et al.
Am. J. Neuroradiol. 1999;20:1009-1014.
ABSTRACT | FULL TEXT  

Pathologic findings of silent, small hyperintense foci in the basal ganglia and thalamus on MRI
Takao et al.
Neurology 1999;52:666-666.
ABSTRACT | FULL TEXT  

Severe deep white matter lesions and outcome in elderly patients with major depressive disorder: follow up study
O'Brien et al.
BMJ 1998;317:982-984.
ABSTRACT | FULL TEXT  

Cerebral Magnetic Resonance T2 High Intensities in End-Stage Renal Disease
Suzuki et al.
Stroke 1997;28:2528-2531.
ABSTRACT | FULL TEXT  

Subcortical Hypoperfusion Associated With Asymptomatic White Matter Lesions on Magnetic Resonance Imaging
Hatazawa et al.
Stroke 1997;28:1944-1947.
ABSTRACT | FULL TEXT  

Pathogenesis of Leukoaraiosis : A Review
Pantoni and Garcia
Stroke 1997;28:652-659.
ABSTRACT | FULL TEXT  

Status of Risk Factors for Dementia Associated With Stroke
Gorelick
Stroke 1997;28:459-463.
ABSTRACT | FULL TEXT  

Magnetic Resonance Imaging in Patients With Low-Tension Glaucoma
Wilson
Arch Ophthalmol 1996;114:105-105.
ABSTRACT  

Magnetic Resonance Imaging Cerebral Abnormalities and Neuropsychologic Test Performance in Elderly Hypertensive Subjects: A Case-Control Study
Schmidt et al.
Arch Neurol 1995;52:905-910.
ABSTRACT  

White Matter Hyperintensities on MRI in the Neurologically Nondiseased Elderly : Analysis of Cohorts of Consecutive Subjects Aged 55 to 85 Years Living at Home
Ylikoski et al.
Stroke 1995;26:1171-1177.
ABSTRACT | FULL TEXT  

The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger's Report : A Review
Pantoni and Garcia
Stroke 1995;26:1293-1301.
ABSTRACT | FULL TEXT  

Magnetic Resonance Imaging in Patients With Low-Tension Glaucoma
Stroman et al.
Arch Ophthalmol 1995;113:168-172.
ABSTRACT