 |
 |

Cerebral Brain Metabolism in Adult Dyslexic Subjects Assessed With Positron Emission Tomography During Performance of an Auditory Task
Jennifer O. Hagman, MD;
Frank Wood, PhD;
Monte S. Buchsbaum, MD;
Paula Tallal, PhD;
Lynn Flowers, PhD;
William Katz, PhD
Arch Neurol. 1992;49(7):734-739.
Abstract
Ten dyslexic adults (aged 33.5±7.3 years, nine men, one woman) and 10 age-, sex- and handedness-matched control subjects (aged 33.6±5.8 years) performed an auditory syllable discrimination task during 18-fluoro-2-deoxyglucose uptake, and then underwent positron emission tomographic scans. A second normal control group performed an analogous visual discrimination task. Dyslexic subjects experienced greater difficulty and made significantly more errors in performing the auditory task. There were no differences in brain metabolic rates in lateral cortical areas (frontal, parietal, temporal, and occipital lobes). A significant difference emerged in the medial temporal lobe, with dyslexic subjects having significantly higher absolute and relative brain metabolism along an anterior-posterior gradient than normal adults. These data support the hypothesis of altered cerebral processing of auditory stimuli in patients with dyslexia.
Author Affiliations
From the Department of Psychiatry and Human Behavior, University of California, Irvine (Dr Hagman); Department of Psychiatry, Bowman-Gray School of Medicine, Winston-Salem, NC (Drs Wood and Flowers); Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ (Dr Tallal); Callier Center for Communications Disorder, University of Texas, Dallas (Dr Katz); and Department of Psychiatry, Mt Sinai School of Medicine, New York, NY (Dr Buchsbaum).
Footnotes
Accepted for publication February 18, 1992.
Reprint requests to the Department of Psychiatry and Human Behavior, University of California Medical Center, 101 City Dr South (Route 88), Orange, CA 92668 (Dr Hagman).
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Neural Mechanisms of Language-Based Learning Impairments: Insights from Human Populations and Animal Models
Fitch and Tallal
Behav Cogn Neurosci Rev 2003;2:155-178.
ABSTRACT
The neurological basis of developmental dyslexia: An overview and working hypothesis
Habib
Brain 2000;123:2373-2399.
ABSTRACT
| FULL TEXT
Explicit and implicit processing of words and pseudowords by adult developmental dyslexics: A search for Wernicke's Wortschatz?
Brunswick et al.
Brain 1999;122:1901-1917.
ABSTRACT
| FULL TEXT
Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks
Richards et al.
Am. J. Neuroradiol. 1999;20:1393-1398.
ABSTRACT
| FULL TEXT
Cognitive Neuropsychological and Regional Cerebral Blood Flow Study of a Developmentally Dyslexic Japanese Child
Kaneko et al.
J Child Neurol 1998;13:457-461.
The Functional Organization of Brain for Reading and Reading Disability (Dyslexia
Shaywitz et al.
Neuroscientist 1996;2:245-255.
ABSTRACT
Cortical Plasticity Underlying Perceptual, Motor, and Cognitive Skill Development: Implications for Neurorehabilitation
Merzenich et al.
Cold Spring Harb Symp Quant Biol 1996;61:1-8.
ABSTRACT
Normal Activation of Frontotemporal Language Cortex in Dyslexia, as Measured With Oxygen 15 Positron Emission Tomography
Rumsey et al.
Arch Neurol 1994;51:27-38.
ABSTRACT
Disruption of the neural response to rapid acoustic stimuli in dyslexia: Evidence from functional MRI
Temple et al.
Proc. Natl. Acad. Sci. USA 2000;97:13907-13912.
ABSTRACT
| FULL TEXT
|