Immunodiagnosis of neurocysticercosis. Disappointing performance of serology (enzyme-linked immunosorbent assay) in an unbiased sample of neurological patients
M. Ramos-Kuri, R. M. Montoya, A. Padilla, T. Govezensky, M. L. Diaz, E. Sciutto, J. Sotelo and C. Larralde
National Institute of Neurology and Neurosurgery of Mexico, Mexico City.
To ascertain the reliability of serological diagnosis of neurocysticercosis
in the everyday a priori situation of neurological consultation, the
enzyme-linked immunosorbent assay test was used to predict the eventual
diagnosis of neurocysticercosis in an unselected sample of 1064 consecutive
neurological cases. Results showed 69% sensitivity and 71% specificity of
the enzyme-linked immunosorbent assay test for the diagnosis of
neurocysticercosis. In sharp contrast with publications that have
proclaimed the excellent diagnostic performance of immunodiagnostic tests,
our results suggest that identification of serum antibodies with standard
enzyme-linked immunosorbent assay techniques is of little value when
applied to a large and heterogeneous group of neurological patients in an
endemic area of cysticercosis, and our results urge a reevaluation of
currently used immunodiagnostic tests that are practiced in the serum of
suspected cases.
Detection of HP10 antigen in serum for diagnosis and follow-up of subarachnoidal and intraventricular human neurocysticercosis
Fleury et al.
J. Neurol. Neurosurg. Psychiatry 2007;78:970-974.
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Topical Review: Neurocysticercosis in Children
Singhi and Singhi
J Child Neurol 2004;19:482-492.
ABSTRACT
Characterization of the 8-Kilodalton Antigens of Taenia solium Metacestodes and Evaluation of Their Use in an Enzyme-Linked Immunosorbent Assay for Serodiagnosis
Hancock et al.
J. Clin. Microbiol. 2003;41:2577-2586.
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SIMILAR DIAGNOSTIC PERFORMANCE FOR NEUROCYSTICERCOSIS OF THREE GLYCOPROTEIN PREPARATIONS FROM TAENIA SOLIUM METACESTODES
VILLOTA et al.
Am J Trop Med Hyg 2003;68:276-280.
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Proposed diagnostic criteria for neurocysticercosis
Del Brutto et al.
Neurology 2001;57:177-183.
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Two Epitopes Shared by Taenia crassiceps and Taenia solium Confer Protection against Murine T. crassiceps Cysticercosis along with a Prominent T1 Response
Toledo et al.
Infect. Immun. 2001;69:1766-1773.
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Neurocysticercosis and epilepsy in developing countries
Pal et al.
J. Neurol. Neurosurg. Psychiatry 2000;68:137-143.
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Serological Diagnosis of Human Cysticercosis by Use of Recombinant Antigens from Taenia solium Cysticerci
Hubert et al.
CVI 1999;6:479-482.
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Towards a Taenia solium Cysticercosis Vaccine: an Epitope Shared by Taenia crassiceps and Taenia solium Protects Mice against Experimental Cysticercosis
Toledo et al.
Infect. Immun. 1999;67:2522-2530.
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