Immunodiagnosis of Neurocysticercosis: Disappointing Performance of Serology (Enzyme-Linked Immunosorbent Assay) in an Unbiased Sample of Neurological Patients

doi:10.1001/archneur.1992.00530300069012

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Vol. 49 No. 6, June 1992

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Immunodiagnosis of Neurocysticercosis

Disappointing Performance of Serology (Enzyme-Linked Immunosorbent Assay) in an Unbiased Sample of Neurological Patients

Manuel Ramos-Kuri, MD; Rosa Maria Montoya, MSc; Alesandro Padilla; Tzipe Govezensky; Maria Luisa Diaz; Eoda Sciutto, PhD; Julio Sotelo, MD; Carlos Larralde, MD

Arch Neurol. 1992;49(6):633-636.

Abstract

• To ascertain the reliability of serological diagnosisof neurocysticercosis in the everyday a priori situation ofneurological consultation, the enzyme-linked immunosorbent assaytest was used to predict the eventual diagnosis of neurocysticercosisin an unselected sample of 1064 consecutive neurological cases.Results showed 69% sensitivity and 71% specificity of the enzyme-linkedimmunosorbent assay test for the diagnosis of neurocysticercosis.In sharp contrast with publications that have proclaimed theexcellent diagnostic performance of immunodiagnostic tests,our results suggest that identification of serum antibodieswith standard enzyme-linked immunosorbent assay techniques isof little value when applied to a large and heterogeneous groupof neurological patients in an endemic area of cysticercosis,and our results urge a reevaluation of currently used immunodiagnostictests that are practiced in the serum of suspected cases.

Author Affiliations

From the National Institute of Neurology and Neurosurgery of Mexico, Mexico City (Drs Ramos-Kuri and Sotelo), and the Institute of Biomedical Investigations, National Autonomous University of Mexico, Mexico City (Drs Sciutto, and Larralde, Mss Montoya, Govezensky, and Díaz, and Mr Padilla).

Footnotes

Accepted for publication December 3, 1991.

Reprint requests to Instituto de Investigaciones Biomédicas,UNAM, Apdo Postal 70228, 04510 México, DF México(Dr Larralde).

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