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Teus van Laar, MD; Ernst N. H. Jansen, MD; A. W. Guus Essink, PharmD; Cees Neef, PhD

Arch Neurol. 1992;49(5):482-484.

Abstract
• The efficacy of intranasal apomorphine was assessed in seven patients with Parkinson's disease and severe levodopa (L-dopa)—related "off-period" disabilities. All patients responded favorably to treatment with intranasal apomorphine. The speed and the quality of motor response and the pharmacokinetic profile showed results similar to those seen after subcutaneous injection of apomorphine administered by insulin pen syringe. The simplicity in the technique of intranasal apomorphine administration was found to be superior by all patients.

Author Affiliations
From the Departments of Neurology (Drs van Laar and Jansen) and Clinical Pharmacy (Drs Essink and Neef), Hospital Medisch Spectrum Twente, Er Enschede, the Netherlands.

Footnotes
Accepted for publication November 12, 1991.

Reprint requests to Department of Neurology, Hospital Medisch Spectrum Twente, 7513 Er Enschede, the Netherlands (Dr Jansen).

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