Decline in Cognitive Performance in Aging Twins: Heritability and Biobehavioral Predictors From the National Heart, Lung, and Blood Institute Twin Study

doi:10.1001/archneur.1992.00530290058012

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Vol. 49 No. 5, May 1992

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Decline in Cognitive Performance in Aging Twins

Heritability and Biobehavioral Predictors From the National Heart, Lung, and Blood Institute Twin Study

Gary E. Swan, PhD; Asenath LaRue, PhD; Dorit Carmelli, PhD; Terry E. Reed, PhD, MPH; Richard R. Fabsitz, MA

Arch Neurol. 1992;49(5):476-481.

Abstract

• The present study examined the contribution of geneticfactors to Digit Symbol performance and its decline in 23 monozygotictwin pairs (mean age at examination 1, 57.1 years) and 21 dizygotictwin pairs (mean age at examination 1, 56.3 years). These menwere assessed twice during a 5-year interval as part of theNational Heart, Lung, and Blood Institute Twin Study. The prevalenceof decline (a change, >1 SD) during the 5-year interval was35% and 39% for monozygotic and dizygotic twins, respectively.The pairwise concordance for decline was 45% in monozygoticand 8% in dizygotic twin pairs, suggesting a possible role forgenetic factors in the decline in Digit Symbol performance inthis sample. A comparison of baseline biologic and behavioralcharacteristics within monozygotic twin pairs discordant fordecline in Digit Symbol performance revealed that declinershad higher initial systolic blood pressures, lower serum cholesterollevels, and lower heart rates than nondecliners.

Author Affiliations

From the Health Sciences Program, SRI International, Menlo Park, Calif (Drs Swan and Carmelli), the Department of Psychiatry and Behavioral Sciences, UCLA School of Medicine (Dr LaRue), the Department of Medical Genetics, Indiana University School of Medicine, Indianapolis (Dr Reed), and the Division of Epidemiology, National Heart, Lung, and Blood Institute, Bethesda, Md (Mr Fabsitz).

Footnotes

Accepted for publication January 15, 1992.

Reprint requests to Health Sciences Program, SRI International,333 Ravenswood Ave, Menlo Park, CA 94025 (Dr Swan).

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