Comparative analysis of computed tomographic and magnetic resonance imaging scans in Alzheimer patients and controls
T. Sandor, F. Jolesz, J. Tieman, R. Kikinis, K. Jones and M. Albert
Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115.
Ten patients with Alzheimer's disease underwent computed tomography and
magnetic resonance imaging at the same point in time. The mean Mini-Mental
State examination score of the patients was 23, indicating that they were
mildly impaired. Ten age-equivalent controls also obtained computed
tomographic and magnetic resonance imaging scans. A semiautomated computer
program analyzed nine comparable regions of interest on each set of scans.
When regions of interest from both types of scans were combined in the same
discriminant function analysis, the first two variables selected were from
the magnetic resonance imaging data set, and they significantly
differentiated 95% of the patients and controls.