Comparative analysis of computed tomographic and magnetic resonance imaging scans in Alzheimer patients and controls

T. Sandor, F. Jolesz, J. Tieman, R. Kikinis, K. Jones and M. Albert
Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115.

Ten patients with Alzheimer's disease underwent computed tomography and magnetic resonance imaging at the same point in time. The mean Mini-Mental State examination score of the patients was 23, indicating that they were mildly impaired. Ten age-equivalent controls also obtained computed tomographic and magnetic resonance imaging scans. A semiautomated computer program analyzed nine comparable regions of interest on each set of scans. When regions of interest from both types of scans were combined in the same discriminant function analysis, the first two variables selected were from the magnetic resonance imaging data set, and they significantly differentiated 95% of the patients and controls.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Structural Modeling of Dynamic Changes in Memory and Brain Structure Using Longitudinal Data From the Normative Aging Study
McArdle et al.
J. Gerontol. B Psychol. Sci. Soc. Sci. 2004;59:P294-P304.
ABSTRACT | FULL TEXT  

Longitudinal Progression of Subclinical Structural Brain Disease in Normal Aging
Cook et al.
AJGP 2004;12:190-200.
ABSTRACT | FULL TEXT  

Cognitive and Physiologic Correlates of Subclinical Structural Brain Disease in Elderly Healthy Control Subjects
Cook et al.
Arch Neurol 2002;59:1612-1620.
ABSTRACT | FULL TEXT  

MRI measures of entorhinal cortex vs hippocampus in preclinical AD
Killiany et al.
Neurology 2002;58:1188-1196.
ABSTRACT | FULL TEXT  

Cognitive and neurobiologic markers of early Alzheimer disease
Albert
Proc. Natl. Acad. Sci. USA 1996;93:13547-13551.
ABSTRACT | FULL TEXT  

Cognitive decline associated with normal aging in rats: a neuropsychological approach.
Zyzak et al.
Learn. Mem. 1995;2:1-16.
ABSTRACT