You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 49 No. 4, April 1992 TABLE OF CONTENTS
  Archives
  •  Online Features
  ORIGINAL CONTRIBUTIONS
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati
What's this?

The Role of Physical Exercise in the Occurrence of Parkinson's Disease

Annie J. Sasco, MD, DrPH; Ralph S. Paffenbarger, Jr, MD, DrPH; Isabelle Gendre; Alwin L. Wing, MBA

Arch Neurol. 1992;49(4):360-365.


Abstract

• A case-control study of Parkinson's disease and physical exercise was conducted in a cohort of 50 002 men who attended Harvard College (Cambridge, Mass) or the University of Pennsylvania (Philadelphia) between 1916 and 1950 and were followed up in adulthood for morbidity and mortality data. Cases of Parkinson's disease were identified from responses to mailed questionnaires and death certificates through 1978. Four controls from the same population were selected for each case. The association between physical activity at the time of college and subsequent risk of Parkinson's disease was evaluated for 137 cases and 548 controls, whereas the data on physical activity in adulthood before the disease occurrence was available only for 94 of these cases. Having belonged to a varsity team or having done regular physical exercise in college was associated with a lower nonsignificant risk of Parkinson's disease. In adulthood, practice of moderate or heavy sports was linked to a reduced risk, although more precise analysis revealed that there was only a modest nonsignificant reduction in risk for subjects who do a moderate amount of physical exercise, but this negative association disappears at higher levels of physical expenditure. These results, which require further confirmation, are compatible with a slight protective effect of physical exercise on the risk of Parkinson's disease, although the lack of association cannot be refuted.



Author Affiliations

From the Unit of Analytical Epidemiology, International Agency for Research on Cancer (Dr Sasco), and Research and Training Unit of Lyon-Nord, Claude Bernard University (Ms Gendre), Lyon, France; Department of Epidemiology, Harvard University School of Public Health, Boston, Mass (Drs Sasco, Paffenbarger, and Wing); and the Department of Health Research and Policy, Stanford (Calif) University School of Medicine (Dr Paffenbarger). Dr Sasco is on secondment from the National Institute of Health and Medical Research (INSERM), France.


Footnotes

Accepted for publication November 6, 1991.

Reprint requests to Unit of Analytical Epidemiology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France (Dr Sasco).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Body Mass Index and Risk of Parkinson's Disease: A Prospective Cohort Study
Logroscino et al.
Am J Epidemiol 2007;166:1186-1190.
ABSTRACT | FULL TEXT  

Physical activity and risk of Parkinson's disease: a prospective cohort study
Logroscino et al.
J. Neurol. Neurosurg. Psychiatry 2006;77:1318-1322.
ABSTRACT | FULL TEXT  

Physical activity and the risk of Parkinson disease
Chen et al.
Neurology 2005;64:664-669.
ABSTRACT | FULL TEXT  

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
Maswood et al.
Proc. Natl. Acad. Sci. USA 2004;101:18171-18176.
ABSTRACT | FULL TEXT  

Book Review: Forced Limb-Use and Recovery following Brain Injury
Tillerson and Miller
Neuroscientist 2002;8:574-585.
ABSTRACT  

Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine
Tillerson et al.
J. Neurosci. 2001;21:4427-4435.
ABSTRACT | FULL TEXT  

Evaluation of a nurse-led multidisciplinary neurological rehabilitation programme using the Nottingham Health Profile
Sitzia et al.
Clin Rehabil 1998;12:389-394.
ABSTRACT  

Heart Rate and Perceived Exertion Measures During Exercise in People with Parkinson's Disease
Hooker et al.
Neurorehabil Neural Repair 1996;10:101-105.
ABSTRACT  

Effects of Rehabilitation Therapy on Parkinsonians' Disability and Functional Independence
Patti et al.
Neurorehabil Neural Repair 1996;10:223-231.
ABSTRACT  

Aerobic Exercise and Early Parkinson's Disease
Bridgewater and Sharpe
Neurorehabil Neural Repair 1996;10:233-241.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1992 American Medical Association. All Rights Reserved.