This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Frederick W. Foley, PhD; Ute Traugott, MD; Nicholas G. LaRocca, PhD; Charles R. Smith, MD; Karen R. Perlman, PhD; Lauren S. Caruso, MS; Labe C. Scheinberg, MD

Arch Neurol. 1992;49(3):238-244.

Abstract
• This study examined psychologic distress and immune function in patients with chronic-progressive multiple sclerosis participating in a placebo-control trial of cyclosporine. Immune measures included percentages and absolute numbers of CD2+, CD4+, CD8+, Leu-11-b+, HLA-DR (IA+), and transferrin-receptor-positive cells, which were evaluated by immunofluorescence using monoclonal antibodies. Distress was measured with self-report scales. The Expanded Disability Status Scale assessed neurologic disability. Subjects were followed up for 2 years, and their high-depressed and low-depressed times were compared. Times of greater depression were associated with lower CD8+ cell numbers and CD8+%, and a higher CD4/CD8 ratio. CD4+ cell numbers and percent were also higher when subjects were depressed, but only in the placebo group. There were no differences in Expanded Disability Status Scale when subjects were more depressed. Evaluation of a single subject revealed that la+ and transferrin-receptor-positive lymphocytes increased 3 months before distress increased. It was concluded that distress is associated with immune dysregulation in multiple sclerosis, although the mechanisms of this association have yet to be delineated.

Author Affiliations
From the Departments of Neurology (Drs Foley, Traugott, La-Rocca, Smith, Perlman, and Scheinberg, and Ms Caruso), Psychiatry (Drs Foley and Scheinberg), Pathology, Neuropathology (Dr Traugott), and Rehabilitation Medicine (Dr Scheinberg), Medical Rehabilitation Research and Training Center for Multiple Sclerosis, Albert Einstein College of Medicine, Bronx, NY.

Footnotes
Accepted for publication October 8, 1991.

Reprint requests to the Medical Rehabilitation Research and Training Center for Multiple Sclerosis, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 (Dr Foley).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Neurobiological mechanisms underlying emotional processing in relapsing-remitting multiple sclerosis
Passamonti et al.
Brain 2009;0:awp095v1-awp095.
ABSTRACT | FULL TEXT  

Pain and affective memory biases interact to predict depressive symptoms in multiple sclerosis
Bruce et al.
Mult Scler 2007;13:58-66.
ABSTRACT  

The risk of multiple sclerosis in bereaved parents: A nationwide cohort study in Denmark
Li et al.
Neurology 2004;62:726-729.
ABSTRACT | FULL TEXT  

When Not Enough Is Too Much: The Role of Insufficient Glucocorticoid Signaling in the Pathophysiology of Stress-Related Disorders
Raison and Miller
Am. J. Psychiatry 2003;160:1554-1565.
ABSTRACT | FULL TEXT  

The relationship between disability and depression in multiple sclerosis: the role of uncertainty, coping, and hope
Lynch et al.
Mult Scler 2001;7:411-416.
ABSTRACT  

Treatment of Depression Is Associated With Suppression of Nonspecific and Antigen-Specific TH1 Responses in Multiple Sclerosis
Mohr et al.
Arch Neurol 2001;58:1081-1086.
ABSTRACT | FULL TEXT  

Multiple sclerosis, disease modifying treatments and depression: a critical methodological review
Feinstein
Mult Scler 2000;6:343-348.
ABSTRACT  

Lesion pattern in patients with multiple sclerosis and depression
Berg et al.
Mult Scler 2000;6:156-162.
ABSTRACT  

Modalities of fatigue in multiple sclerosis: correlation with clinical and biological factors
lriarte et al.
Mult Scler 2000;6:124-130.
ABSTRACT  

The relationship of MS to physical trauma and psychological stress: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
Goodin et al.
Neurology 1999;52:1737-1737.
FULL TEXT  

Mood Disorders and Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Multiple Sclerosis: Association With Cerebral Inflammation
Fassbender et al.
Arch Neurol 1998;55:66-72.
ABSTRACT | FULL TEXT  

What Do We Really Know About Cognitive Dysfunction, Affective Disorders, and Stress in Multiple Sclerosis? A Practitioner's Guide
Fischer et al.
Neurorehabil Neural Repair 1994;8:151-164.
ABSTRACT