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Miguel A. Pagano, MD; Pedro E. Cahn, MD; María L. Garau, MD; Carlos A. Mangone, MD; Héctor A. Figini, MD; Alberto A. Yorio, MD; María C. Dellepiane, MD; Mirtha G. Amores, MD; Héctor M. Perez, MD; Arnaldo D. Casiró, MD

Arch Neurol. 1992;49(2):166-169.

Abstract
• Brain-stem auditory evoked potentials were recorded in 35 human immunodeficiency virus (HIV)—seropositive subjects from the Centers for Disease Control groups III and IV, 24 HIV-negative drug abusers, and 62 normal healthy controls. None of the patients had evidence of neurological complications. History of alcohol consumption was an exclusion criterion. The values of central conduction times I-V and III-V showed significant differences between the HIV-seropositive subjects and normal healthy controls, as well as between the HIV-seropositive subjects and HIV-negative drug abusers. Central conduction times I-III showed no differences between groups, except in the left ear of Centers for Disease Control group IV compared with controls. No statistical differences were found in the central conduction times between HIV-negative drug abusers and normal healthy controls. The results suggest a subclinical involvement of the upper brain stem in HIV infection. It could be produced by direct action of the virus on central nervous system structures.

Author Affiliations
From the Departments of Neurology (Drs Pagano, Garau, Mangone, Figini, Yorio, Dellepiane, and Amore) and Infectology (Drs Cahn, Perez, and Casiró), Fernandez Hospital, Buenos Aires, Argentina.

Footnotes
Accepted for publication June 4, 1991.

Reprint requests to Clinical Neurophysiology Section, Neurological Unit, Fernandez Hospital, Cerviño 3356, Buenos Aires (1425), Argentina (Dr Pagano).

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