In vivo phosphorus magnetic resonance spectroscopy in multiple sclerosis
J. M. Minderhoud, E. L. Mooyaart, R. L. Kamman, A. W. Teelken, M. C. Hoogstraten, L. M. Vencken, E. J. Gravenmade and W. van den Burg
Department of Neurology, University Hospital, Groningen, The Netherlands.
Localized phosphorus magnetic resonance spectroscopy at 1.5 T was performed
in 39 patients with multiple sclerosis and in 15 healthy controls. The
multiple sclerosis spectra showed increased creatine phosphate levels. This
increase was correlated with the severity of the handicap and was greater
in patients with a progressive course of the disease than in patients with
relapsing-remitting disease. No clear abnormalities were observed in the
spectra of patients with multiple sclerosis regarding the
phosphomonoesters, phosphodiesters, inorganic phosphate, and beta-adenosine
triphosphate or with respect to pH values. There was an increased creatine
phosphate level in the spectra in relation to a low metabolic state of the
brain.
