You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 49 No. 2, February 1992 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

In vivo phosphorus magnetic resonance spectroscopy in multiple sclerosis

J. M. Minderhoud, E. L. Mooyaart, R. L. Kamman, A. W. Teelken, M. C. Hoogstraten, L. M. Vencken, E. J. Gravenmade and W. van den Burg
Department of Neurology, University Hospital, Groningen, The Netherlands.

Localized phosphorus magnetic resonance spectroscopy at 1.5 T was performed in 39 patients with multiple sclerosis and in 15 healthy controls. The multiple sclerosis spectra showed increased creatine phosphate levels. This increase was correlated with the severity of the handicap and was greater in patients with a progressive course of the disease than in patients with relapsing-remitting disease. No clear abnormalities were observed in the spectra of patients with multiple sclerosis regarding the phosphomonoesters, phosphodiesters, inorganic phosphate, and beta-adenosine triphosphate or with respect to pH values. There was an increased creatine phosphate level in the spectra in relation to a low metabolic state of the brain.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Creatine and Creatinine Metabolism
Wyss and Kaddurah-Daouk
Physiol. Rev. 2000;80:1107-1213.
ABSTRACT | FULL TEXT  

Normal-appearing white matter changes in multiple sclerosis: the contribution of magnetic resonance techniques
Filippi et al.
Mult Scler 1999;5:273-282.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1992 American Medical Association. All Rights Reserved.