 |
 |

Locus Coeruleus Involvement in Huntington's Disease
Richard M. Zweig, MD;
C. A. Ross, MD, PhD;
J. C. Hedreen, MD;
C. Peyser, MD;
Joseph E. Cardillo, PhD;
S. E. Folstein, MD;
D. L. Price, MD
Arch Neurol. 1992;49(2):152-156.
Abstract
 |  |
Numbers and areas of neuronal profiles from sections of brain stem at specific anatomic levels of the locus coeruleus and the dorsal raphe nucleus were measured in 33 patients with Huntington's disease and in 23 age-matched control subjects. Results from the Huntington's disease cases were correlated with severity of neostriatal atrophy and with systematically collected quantitative clinical data. Among the patients with Huntington's disease, lower locus coeruleus neuronal counts, reduced neuronal areas, and reduced locus coeruleus length (distance between rostral and caudal levels) were associated with features of advanced disease, including severity of neostriatal atrophy, severity of dementia, duration of illness, and severity of motor impairment and activities of daily living impairment. By contrast, there was no evidence of neuronal pathology within the dorsal raphe nucleus in Huntington's disease. Pathologic changes in the locus coeruleus may relate to some of the clinical manifestations of Huntington's disease.
Author Affiliations
From the Department of Internal Medicine, Neurology Division (Dr Zweig) and Research Office (Dr Cardillo), Veterans Affairs Medical Center, and the University of Nevada School of Medicine, Reno; and the Departments of Psychiatry (Drs Ross, Peyser, and Folstein), Neuroscience (Drs Ross and Price), Pathology (Drs Hedreen and Price), Medicine and Pediatrics (Dr Folstein), and Neurology (Dr Price), The Johns Hopkins University School of Medicine, Baltimore, Md.
Footnotes
Accepted for publication August 29, 1991.
Reprint requests to the Veterans Affairs Medical Center, 1000 Locust St, Reno, NV 89520 (Dr Zweig).
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Restoration of Norepinephrine-Modulated Contextual Memory in a Mouse Model of Down Syndrome
Salehi et al.
Sci Transl Med 2009;1:7ra17-7ra17.
ABSTRACT
| FULL TEXT
Rapid Eye Movement Sleep Disturbances in Huntington Disease
Arnulf et al.
Arch Neurol 2008;65:482-488.
ABSTRACT
| FULL TEXT
Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons
Holm et al.
Development 2003;130:3535-3545.
ABSTRACT
| FULL TEXT
The distribution of structural neuropathology in pre-clinical Huntington's disease
Thieben et al.
Brain 2002;125:1815-1828.
ABSTRACT
| FULL TEXT
Topical Review: Basal Ganglia: Functional Anatomy and Physiology. Part 2
Afifi
J Child Neurol 1994;9:352-361.
ABSTRACT
|