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Patricia J. Karstaedt, MD; Jonathan H. Pincus, MD

Arch Neurol. 1992;49(2):149-151.

Abstract
• Forty-three carbidopa-levodopa (Sinemet)-treated parkinsonian patients with protein-sensitive motor fluctuations were started on the protein redistribution diet within the past 48 months. Thirty patients (70%) are still using the diet successfully after more than 12 months (mean duration, 33.6 months; range, 12 to 48 months). The diet was discontinued in the other 13 cases. In 10 of these 13 patients, the protein redistribution diet was discontinued for a variety of reasons, despite continued sensitivity to dietary protein; in only three patients (7%), those with the most severe and complicated disease, was the protein redistribution diet stopped because of its limited therapeutic benefit. The protein redistribution diet is a simple adjunct to the treatment of Parkinson's disease that can significantly prolong the efficacy of levodopa therapy in many fluctuating "end-stage" patients.

Author Affiliations
From the Department of Neurology, Georgetown University Hospital, Washington, DC.

Footnotes
Accepted for publication August 9, 1991.

Reprint requests to Department of Neurology, Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (Dr Pincus).

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