This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Prominent Role of Cortical Lesions

Olivier Godefroy, MD; Marc Rousseaux, MD, PhD; Didier Leys, MD; Alain Destée, MD; Philip Scheltens, MD; Jean Pierre Pruvo, MD

Arch Neurol. 1992;49(12):1285-1289.

Abstract
• Most studies on frontal lobe dysfunction (FLD) in patients with striatal lesions did not consider possible associated cortical lesions not seen on computed tomographic scans. To determine the possible role of such cortical lesions, we assessed FLD in 10 patients with unilateral lenticulostriate infarct on computed tomographic scans. Magnetic resonance imaging revealed an associated cortical infarct not seen on computed tomographic scans in four patients. Using a battery of neuropsychological tests sensitive to FLD, we found that (1) the crossed tapping test was the only FLD test significantly disturbed in patients with pure unilateral lenticulostriate infarcts, (2) FLD was only present in patients with associated cortical infarct, and (3) caudate lesions only account for the number of echopraxic errors in the crossed tapping test. We conclude that unilateral isolated lenticulostriate infarcts might not lead to FLD, even though they may disturb the development of strategies involved in motor procedural learning.

Author Affiliations
From the Departments of Neurology (Drs Godefroy, Leys, and Destée), Neurological Rehabilitation (Dr Rousseaux), and Neuroradiology (Dr Pruvo), University Hospital, Lille, France; and Department of Neurology, Free University Hospital, Amsterdam, the Netherlands (Dr Scheltens).

Footnotes
Accepted for publication May 12, 1992.

Reprint requests to Service de Neurologie B, Hôpital B, F-59037 Lille, France (Dr Godefroy).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Apathy and the Functional Anatomy of the Prefrontal Cortex-Basal Ganglia Circuits
Levy and Dubois
Cereb Cortex 2006;16:916-928.
ABSTRACT | FULL TEXT  

Post-stroke movement disorders: report of 56 patients
Alarcon et al.
J. Neurol. Neurosurg. Psychiatry 2004;75:1568-1574.
ABSTRACT | FULL TEXT  

The frontal lobes are necessary for `theory of mind'
Stuss et al.
Brain 2001;124:279-286.
ABSTRACT | FULL TEXT  

The anatomy of aphasia revisited
Kreisler et al.
Neurology 2000;54:1117-1123.
ABSTRACT | FULL TEXT