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Further Evidence of Immune Activation

Shalini Bansil, MD; Francis A. Mithen, MD, PhD; Bhim S. Singhal, MD, FRCP; Stuart D. Cook, MD; Christine Rohowsky-Kochan, PhD

Arch Neurol. 1992;49(12):1277-1280.

Abstract
• Neopterin is a by-product of guanosine triphosphate metabolism and is produced by macrophages in response to lymphocytic activation. We have studied serum neopterin levels in patients with Guillain-Barré syndrome to obtain further evidence of immune activation in this disease. Serum neopterin levels were significantly elevated in patients with Guillain-Barré syndrome compared with patients with other peripheral neuropathies and multiple sclerosis and with healthy control subjects. Serial analysis demonstrated that as neopterin levels fell, the clinical status of the patients with Guillain-Barré syndrome improved and soluble interleukin 2 receptor levels dropped. Thus, lymphocytic and macrophage activation may play a role in the pathogenesis of Guillain-Barré syndrome.

Author Affiliations
From the Department of Neurosciences, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark (Drs Bansil, Cook, and Rohowsky-Kochan); the Department of Veterans Affairs, John Cochran Medical Center, St Louis, Mo (Dr Mithen); St Louis University, School of Medicine (Dr Mithen); the Department of Neurology, Bombay (India) Hospital (Dr Singhal); and the Neurology Service, Veterans Affairs Medical Center, East Orange, NJ (Dr Cook).

Footnotes
Accepted for publication July 20, 1992.

Reprint requests to University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Department of Neurosciences, MSB H506, 185 S Orange Ave, Newark, NJ 07103 (Dr Bansil).

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