You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 49 No. 12, December 1992 TABLE OF CONTENTS
  Archives
  •  Online Features
  ORIGINAL CONTRIBUTIONS
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Cerebral Glucose Metabolism in Parkinson's Disease With and Without Dementia

Richard F. Peppard, MD; W. R. Wayne Martin, MD; Geoff D. Carr, MD; Edward Grochowski; Michael Schulzer, MD; Mark Guttman, MD; Patrick L. McGeer, MD; Anthony G. Phillips, PhD; Joseph K. C. Tsui; Donald B. Calne, DM

Arch Neurol. 1992;49(12):1262-1268.


Abstract

• Although cognitive impairment is commonly associated with Parkinson's disease, the relative importance of cortical and subcortical pathologic changes to the development of dementia is controversial. Characteristic abnormalities in cortical glucose metabolism have been reported previously in Alzheimer's disease, a disease in which cortical changes predominate. We measured cerebral glucose metabolism with positron emission tomography in 20 control subjects and in 14 patients with PD with mental status ranging from normal to severely demented to determine whether changes in cortical glucose metabolism occur in early PD and whether the degree and pattern of metabolic change relate to the severity of dementia. The patients were divided into demented and nondemented groups according to the results of neuropsychological assessment. Age-adjusted covariance analyses were performed, since the age distribution varied between groups. The nondemented patients with PD showed widespread cortical glucose hypometabolism without any selective temporoparietal defects. The pattern of glucose hypometabolism seen in the demented patients with PD resembled that described in patients with Alzheimer's disease; ie, there was a global decrease in glucose metabolism, with more severe abnormalities observed in the temporoparietal regions.



Author Affiliations

From the Departments of Medicine (Drs Peppard, Martin, Schulzer, Guttman, Tsui, and Calne), Psychology (Drs Carr and Phillips), Psychiatry (Dr McGeer), and Statistics (Dr Schulzer) and the Unversity of British Columbia/TRIUMF Positron Emission Tomography Program (Mr Grochowski), University of British Columbia, Vancouver. Dr Martin is now with the Movement Disorder Clinic, Edmonton (Alberta) General Hospital.


Footnotes

Accepted for publication June 10, 1992.

Reprint requests to Movement Disorder Clinic, Edmonton General Hospital, 11111 Jasper Ave, Edmonton, Alberta, Canada T5K OL4 (Dr Martin).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Occipital hypoperfusion in Parkinson's disease without dementia: correlation to impaired cortical visual processing
Abe et al.
J. Neurol. Neurosurg. Psychiatry 2003;74:419-422.
ABSTRACT | FULL TEXT  

Neuroimaging in Dementia with Lewy Bodies: Metabolism, Neurochemistry, and Morphology
Minoshima et al.
J Geriatr Psychiatry Neurol 2002;15:200-209.
ABSTRACT  

Familial parkinsonism with synuclein pathology: Clinical and PET studies of A30P mutation carriers
Kruger et al.
Neurology 2001;56:1355-1362.
ABSTRACT | FULL TEXT  

Cortical dysfunction in non-demented Parkinson's disease patients: A combined 31P-MRS and 18FDG-PET study
Hu et al.
Brain 2000;123:340-352.
ABSTRACT | FULL TEXT  

Motor correlates of occipital glucose hypometabolism in Parkinson's disease without dementia
Bohnen et al.
Neurology 1999;52:541-541.
ABSTRACT | FULL TEXT  

Cognitive Loss in Dementia With Lewy Bodies and Alzheimer Disease
Shimomura et al.
Arch Neurol 1998;55:1547-1552.
ABSTRACT | FULL TEXT  

Temporal Lobe Perfusion on Single Photon Emission Computed Tomography Predicts the Rate of Cognitive Decline in Alzheimer's Disease
Wolfe et al.
Arch Neurol 1995;52:257-262.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1992 American Medical Association. All Rights Reserved.