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Neurocognitive Effects of Aluminum
Karen I. Bolla, PhD;
Gary Briefel, MD;
David Spector, MD;
Brian S. Schwartz, MD, MS;
Lisa Wieler;
Janice Herron;
Louis Gimenez, MD
Arch Neurol. 1992;49(10):1021-1026.
Abstract
• The neurocognitive effects of aluminum (Al) were studied in 35 hemodialysis patients. Higher Al levels were associated with a decline in visual memory. As Al levels increased, patients with lower vocabulary scores (a measure of premorbid intelligence) showed a decline in attention/concentration, frontal lobe functions, and on several neurocognitive measures, while those with higher vocabulary scores revealed no Al-related decline. These results suggest that individuals with lower verbal intelligence may possess less well-developed compensatory strategies to overcome the neurocognitive effects associated with Al. These data also indicate that Al is neurotoxic and, therefore, potential sources of environmental Al should be identified and eliminated.
Author Affiliations
From the Departments of Neurology, Francis Scott Key Medical Center (Dr Bolla and Mss Wieler and Herron), Psychiatry and Behavioral Science (Dr Bolla), Division of Renal Medicine (Drs Briefel, Spector, and Gimenez), and School of Hygiene and Public Health, Department of Environmental Health Sciences (Drs Bolla and Schwartz), The Johns Hopkins University School of Medicine, Baltimore, Md.
Footnotes
Accepted for publication June 9, 1992.
Presented in part at the 41st annual meeting of the American Academy of Neurology, Chicago, Ill, April 1989.
Reprint requests to the Department of Neurology, The Johns Hopkins University School of Medicine, Francis Scott Key Medical Center, 4940 Eastern Ave, Baltimore, MD 21224 (Dr Bolla).
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