You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 49 No. 1, January 1992 TABLE OF CONTENTS
  Archives
  •  Online Features
  ORIGINAL CONTRIBUTIONS
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Increased Adherence of T Cells to Human Endothelial Cells in Patients With Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy

Katsuhiro Ichinose, MD; Tatsufumi Nakamura, MD; Atsushi Kawakami, MD; Katsumi Eguchi, MD; Kunihiko Nagasato, MD; Kohji Shibayama, MD; Mitsuhiro Tsujihata, MD; Shigenobu Nagataki, MD

Arch Neurol. 1992;49(1):74-76.


Abstract

• We investigated the adherence of T cells to human umbilical vein endothelial cells in seven patients with human T-lymphotropic virus type I (HTLV-I)—associated myelopathy. The adherence of T cells to endothelial cells increased significantly in all the patients with HTLV-I—associated myelopathy when compared with the adherence in the seronegative controls (1.3-to 2.8-fold) and compared with the adherence in the anti—HTLV-I—seropositive non—HTLV-I—associated myelopathy carriers (1.4- to 2.8-fold). Prior treatment of the endothelial cell monolayer with recombinant interferon gamma (50 IU/mL) enhanced the T cell—endothelial cell adhesion in both the controls and patients with HTLV-I—associated myelopathy. However, values after prior treatment in the patients with HTLV-I—associated myelopathy were significantly higher than those in seronegative controls and carriers. The results suggest that the significantly increased T cell—endothelial cell adherence may be related to the initial stages of lymphocyte migration from the blood to the central nervous system in patients with HTLV-I—associated myelopathy.



Author Affiliations

From the First Department of Internal Medicine (Drs Ichinose, Nakamura, Kawakami, Eguchi, Nagasato, Shibayama, and Nagataki), Nagasaki (Japan) University School of Medicine, and School of Allied Medical Sciences (Dr Tsujihata), Nagasaki University.


Footnotes

Accepted for publication August 21, 1991.

Reprint requests to First Department of Internal Medicine, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki 852, Japan (Dr Nagataki).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Bronchoalveolar lymphocytosis correlates with human T lymphotropic virus type I (HTLV-I) proviral DNA load in HTLV-I carriers
Mori et al.
Thorax 2005;60:138-143.
ABSTRACT | FULL TEXT  

Vascular cell adhesion molecule-1 induced by human T-cell leukaemia virus type 1 Tax protein in T-cells stimulates proliferation of human T-lymphocytes
Valentin et al.
J. Gen. Virol. 2001;82:831-835.
ABSTRACT | FULL TEXT  

High prevalence of Sjogren's syndrome in patients with HTLV-I associated myelopathy
Nakamura et al.
Ann Rheum Dis 1997;56:167-172.
ABSTRACT | FULL TEXT  

Exaggerated Messenger RNA Expression of Inflammatory Cytokines in Human T-Cell Lymphotropic Virus Type I--Associated Myelopathy
Watanabe et al.
Arch Neurol 1995;52:276-280.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1992 American Medical Association. All Rights Reserved.