You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 49 No. 1, January 1992 TABLE OF CONTENTS
  Archives
  •  Online Features
  ORIGINAL CONTRIBUTIONS
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Event-Related Potential P300 in Multiple Sclerosis

Relation to Magnetic Resonance Imaging and Cognitive Impairment

Lawrence S. Honig, MD, PhD; R. Eugene Ramsay, MD; William A. Sheremata, MD

Arch Neurol. 1992;49(1):44-50.


Abstract

• Cerebral involvement in multiple sclerosis may result not only in sensory and motor symptoms but also in impaired mentation. We hypothesize that cognitive dysfunction occurs due to cortical deafferentation or disconnection arising from subcortical white-matter disease. We examined the P300 event-related potential in 31 patients with multiple sclerosis, correlating it with disease severity ratings based on magnetic resonance imaging signal intensity changes, cognitive dysfunction, and disability status. The patients with multiple sclerosis exhibited significantly prolonged P300 wave latencies compared with 32 control subjects. The P300 latency was strongly correlated with the presence of demyelinative brain lesions seen on magnetic resonance imaging scans and with cognitive impairment, but was only weakly associated with the Kurtzke disability status score, consistent with this scale primarily reflecting spinal rather than cerebral demyelination. Our study results support a relationship between subcortical white-matter lesions and cognitive impairment in multiple sclerosis.



Author Affiliations

From the Department of Neurology, University of Miami (Fla) School of Medicine (Drs Honig, Ramsay, and Sheremata), and the Neurology Service, Veterans Affairs Medical Center, Miami (Dr Ramsay). Dr Honig is now with the Department of Neurology and Neurological Sciences, Stanford (Calif) University Medical Center.


Footnotes

Accepted for publication June 4, 1991.

Presented as a poster exhibit at the 38th Annual Meeting of the American Academy of Neurology, New Orleans, La, April 29,1986.

Reprint requests to the Department of Neurology and Neurological Sciences (H-3160), Stanford University Medical Center, Stanford, CA 94305-5235 (Dr Honig).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings
Piras et al.
J. Neurol. Neurosurg. Psychiatry 2003;74:878-885.
ABSTRACT | FULL TEXT  

Electrophysiological evidence for a defect in the processing of temporal sound patterns in multiple sclerosis
Jones et al.
J. Neurol. Neurosurg. Psychiatry 2002;73:561-567.
ABSTRACT | FULL TEXT  

Event-Related Auditory Evoked Potentials and Amyotrophic Lateral Sclerosis
Gil et al.
Arch Neurol 1995;52:890-896.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1992 American Medical Association. All Rights Reserved.