This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Michael Weller, MD; Andreas Stevens, MD; Norbert Sommer, MD; Horst Wiethölter, MD; Johannes Dichgans, MD

Arch Neurol. 1991;48(8):837-841.

Abstract
• Intrathecal synthesis of IgM and IgG, oligoclonal immunoglobulin bands, and the levels of fibronectin, soluble interleukin 2 receptor, interleukin 6, and tumor necrosis factor were investigated with the use of enzyme-linked immunosorbent assay in 46 paired cerebrospinal fluid and serum samples from 32 patients with meningopolyradiculoneuritis due to Borrelia burgdorferi (Lyme borreliosis stage 2). Cerebrospinal fluid and serum interleukin 6, although not specific for neuroborreliosis, were good indicators of disease activity, while the serum soluble interleukin 2 receptor level was only mildly elevated. Tumor necrosis factor was never detected in cerebrospinal fluid or serum specimens, and cerebrospinal fluid IgM, IgM index, and cerebrospinal fluid IgM/cerebrospinal fluid IgG ratios were significantly higher than in all other neuroimmunologic disorders evaluated and may be valuable diagnostic indicators for neuroborreliosis. The estimation of intrathecally synthesized IgG and IgM fractions for the differential diagnosis of neuroimmunologic disorders did not add to IgG and IgM index calculations.

Author Affiliations
From the Department of Neurology, University of Tübingen (Federal Republic of Germany).

Footnotes
Accepted for publication November 14, 1990.

Reprint requests to the Department of Neurology, University of Tübingen, Hoppe-Seyler-Strasse 3, 7400 Tübingen, Federal Republic of Germany (Dr Weller).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The chemokine CXCL13 (BLC): A putative diagnostic marker for neuroborreliosis
Rupprecht et al.
Neurology 2005;65:448-450.
ABSTRACT | FULL TEXT  

The Immune Response at Onset and During Recovery From Borrelia burgdorferi Meningoradiculitis
Cepok et al.
Arch Neurol 2003;60:849-855.
ABSTRACT | FULL TEXT