Diagnostic Criteria for Multiple Sclerosis Research Involving Multiply Affected Families

doi:10.1001/archneur.1991.00530200041016

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 48 No. 8, August 1991

Online Only
	•	Online First Table of Contents

ORIGINAL CONTRIBUTIONS

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (55)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Diagnostic Criteria for Multiple Sclerosis Research Involving Multiply Affected Families

Donald E. Goodkin, MD; Teresa H. Doolittle, PA-C, MHP; Stephen S. Hauser, MD; Richard M. Ransohoff, MD; Allen D. Roses, MD; Richard A. Rudick, MD

Arch Neurol. 1991;48(8):805-807.

Abstract

• Existing diagnostic criteria for multiple sclerosis presentsignificant limitations when assessing multiplex families forthree reasons: (1) restricting age of onset to 10 to 50 yearsis likely to exclude 10% of patients known to have a later onset,(2) diagnoses based on subjective information can potentiallyresult in a falsepositive diagnosis, and (3) including progressivemyelopathies occurring within families, particularly when highlysymmetrical, may result in the improper inclusion of geneticallydetermined neurological diseases such as familial spastic paraparesis.The validity of any molecular genetic approach for determiningdisease susceptibility critically depends on diagnostic accuracy.We present adapted diagnostic criteria that address each ofthese diagnostic pitfalls unique to multiplex multiple sclerosisfamily research.

Author Affiliations

From The Cleveland (Ohio) Clinic Foundation, Mellen Center for Multiple Sclerosis Treatment and Research (Drs Goodkin, Ransohoff, and Rudick); the Neuroimmunology Unit, Massachusetts General Hospital, Boston (Dr Hauser and Ms Doolittle); and the Department of Neurology, Duke University Medical Center, Durham, NC (Dr Roses).

Footnotes

Accepted for publication September 12, 1990.

Reprint requests to The Cleveland Clinic Foundation, MellenCenter for Multiple Sclerosis Treatment and Research, 9500 EuclidAve (U-10), Cleveland, OH 44195. (Dr Goodkin).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility
Couturier et al.
Brain 2011;134:693-703.
ABSTRACT | FULL TEXT

Familial effects on the clinical course of multiple sclerosis
Hensiek et al.
Neurology 2007;68:376-383.
ABSTRACT | FULL TEXT

Men transmit MS more often to their children vs women: the Carter effect.
Kantarci et al.
Neurology 2006;67:305-310.
ABSTRACT | FULL TEXT

APOE epsilon variation in multiple sclerosis susceptibility and disease severity: Some answers
Burwick et al.
Neurology 2006;66:1373-1383.
ABSTRACT | FULL TEXT

Multiple susceptibility loci for multiple sclerosis
The Multiple Sclerosis Genetics Group et al.
Hum Mol Genet 2002;11:2251-2256.
ABSTRACT | FULL TEXT

Genetic basis for clinical expression in multiple sclerosis
The Multiple Sclerosis Genetics Group et al.
Brain 2002;125:150-158.
ABSTRACT | FULL TEXT

Altered nerve growth factor level in the optic nerve of patients affected by multiple sclerosis
Micera et al.
Mult Scler 1999;5:389-394.
ABSTRACT

Evidence for the genetic role of human leukocyte antigens in low frequency DRBI*1501 multiple sclerosis patients in Israel
Karni et al.
Mult Scler 1999;5:410-415.
ABSTRACT

Familial factors influence disability in MS multiplex families
Brassat et al.
Neurology 1999;52:1632-1632.
ABSTRACT | FULL TEXT

Multiple sclerosis associated with uveitis in two large clinic-based series
Biousse et al.
Neurology 1999;52:179-179.
ABSTRACT | FULL TEXT

Linkage of the MHC to Familial Multiple Sclerosis Suggests Genetic Heterogeneity
The Multiple Sclerosis Genetics Group et al.
Hum Mol Genet 1998;7:1229-1234.
ABSTRACT | FULL TEXT

Chromosome 19 Single-Locus and Multilocus Haplotype Associations With Multiple Sclerosis: Evidence of a New Susceptibility Locus in Caucasian and Chinese Patients
Barcellos et al.
JAMA 1997;278:1256-1261.
ABSTRACT

| | |