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Validation of a New Clinical Interview to Assist Neuropathologic Study

Paula B. Davis, MD; Heidi White, MD; Joseph L. Price, PhD; Daniel McKeel, MD; Lee N. Robins, PhD

Arch Neurol. 1991;48(6):613-617.

Abstract
• Neuropathologic studies of dementia and normal aging suffer from a lack of individuals examined for the presence and severity of dementia before death. To increase clinical information in such cases, a retrospective collateral interview was developed. Thirty-nine individuals were studied; 27 had autopsies. In all cases, the autopsy confirmed the Retrospective Collateral Dementia Interview (RCDI) diagnosis of the presence or absence of dementia; the RCDI had a sensitivity of 88% and a specificity of 80% for specifically detecting probable Alzheimer's disease. Agreement between the RCDI and premortem diagnosis was 96%; between RCDI and medical records, 100%. Agreement between RCDI staging of dementia severity and the last assessment of the living subject was 70%; between the RCDI and a brief staging at death, 86%. This validation confirms the value of postmortem interviews with close informants to assess dementia presence and severity.

Author Affiliations
From the Program on Aging, Department of Medicine (Drs Davis and White), the Departments of Anatomy and Neurobiology (Dr Price), Pathology (Dr McKeel), and Psychiatry (Dr Robins), and the Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Mo. Dr Davis is now with the Section of Geriatrics, University of Pittsburgh (Pa).

Footnotes
Accepted for publication November 19, 1990.

Presented as a poster exhibit at the American Geriatrics Society Meeting, Boston, Mass, May 12-13,1989.

Reprint requests to Section of Geriatrics, University of Pittsburgh, B-45 Lothrop Hall, 190 Lothrop St, Pittsburgh, PA 15213 (Dr Davis).

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