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Electrophysiologic Manifestations of Early Alzheimer's Disease

Leyla deToledo-Morrell, PhD; Susan Evers; Thomas J. Hoeppner, PhD; Frank Morrell, MD, MSc; David C. Garron, PhD; Jacob H. Fox, MD

Arch Neurol. 1991;48(6):605-609.

Abstract
• Long-latency event-related potentials (P300) were assessed in patients wth early probable Alzheimer's disease (AD), age-matched controls, and young adults during a task that imposed various degrees of demand on memory. Although patients with AD did not differ from age-matched controls when one item had to be remembered, their P300 potential was dramatically reduced in amplitude or absent with increasing memory load. Aged controls did not differ from young adults on this mesuer. P300 latency, however, did not differentiate patients with AD. Thus, electrophysiological abnormalities detected in the context of mnemonic demand may provide a sensitive marker of the early stages of probable AD.

Author Affiliations
From the Departments of Neurological Sciences (Drs deToledo-Morrell, Fox, Hoeppner, and Morrell and Ms Evers) and Psychology and Social Sciences (Drs deToledo-Morrell and Garron), and the Rush Alzheimer's Disease Center (Dr Fox), Rush Medical College, Chicago, Ill.

Footnotes
Accepted for publication December 4, 1990.

Presented in part at the annual meeting of the Society for Neuroscience, Toronto, Canada, November 13-18,1988.

Reprint requests to Rush Medical College, 1653 W Congress Pkwy, Chicago, IL 60612 (Dr deToledo-Morrell).

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