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Adele D. Sadovnick, PhD; Dennis E. Bulman, MSc; Lara Hashimoto; Marie B. D'Hooghe, MD; George C. Ebers, MD

Arch Neurol. 1991;48(6):586-588.

Abstract
• A population-based study of pairs of relatives (siblings, second- and third-degree) concordant for multiple sclerosis did not show an excess of like-sexed pairs. In addition, data on human lymphocyte antigen typing for sibling pairs concordant for multiple sclerosis did not find an increase in haplotype sharing for like-sexed pairs. These data do not support the notion that sex-related factors influence multiple-sclerosis susceptibility in families.

Author Affiliations
From the Department of Medical Genetics and Multiple Sclerosis Clinic, University Hospital—University of British Columbia Site, University of British Columbia, Vancouver (Dr Sadovnick); and Multiple Sclerosis Clinic, University Hospital, University of Western Ontario, London (Mr Bulman, Ms Hashimoto, and Drs D'Hooghe and Ebers).

Footnotes
Accepted for publication December 4, 1990.

Reprint requests to Department of Medical Genetics, University of British Columbia, 226-6174 University Blvd, Vancouver, British Columbia, Canada V6T 1Z3 (Dr Sadovnick).

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