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Glutethimide Treatment of Disabling Action Tremor in Patients With Multiple Sclerosis and Traumatic Brain Injury
Mindy L. Aisen, MD;
Mary Holzer, MS, OTR;
Michael Rosen, PhD;
Mark Dietz, MD;
Fletcher McDowell, MD
Arch Neurol. 1991;48(5):513-515.
Abstract
• Glutethimide has been used to control essential tremor. Its efficacy in the treatment of disabling cerebellar and rubral tremor was assessed in an open study of six patients with multiple sclerosis and two patients with traumatic brain injury. Functional and quantitative tremor severity was assessed before treatment and 7 to 14 days after a stable dose was achieved. Six of eight patients exhibited visible functional benefit from treatment with glutethimide; abstract testing results correlated well with functional status in most cases. Four patients chose to continue to receive medication. Controlled trials of glutethimide to compare its efficacy with that of other medications used in the treatment of action tremor are indicated.
Author Affiliations
From The Burke Rehabilitation Center. White Plains, NY (Drs Aisen and McDowell and Ms Holzer); the Massachusetts Institute of Technology, Cambridge (Dr Rosen); and the Rocky Mountain Multiple Sclerosis Center, Denver, Colo (Dr Dietz).
Footnotes
Accepted for publication December 21, 1990.
Reprint requests to The Burke Rehabilitation Center, 785 Mamaroneck Ave, White Plains, NY 10605 (Dr Aisen).
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