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Ranjan Duara, MD; Alex Kushch; Karen Gross-Glenn, PhD; W. William Barker, MS; Bonnie Jallad, MS; Shlomo Pascal, MD; David A. Loewenstein, PhD; Jerome Sheldon, MD; Mark Rabin, PhD; Bonnie Levin, PhD; Herbert Lubs, MD

Arch Neurol. 1991;48(4):410-416.

Abstract
• The areas of six bilateral brain segments in the right and left hemispheres, on a horizontal brain section, and the area of subdivisions of the corpus callosum, on a midsagittal brain section, were measured on magnetic resonance images obtained from 21 dyslexic and 29 control subjects. In the entire group, the frontal half of the horizontal brain section showed asymmetry, with the right side being larger, whereas posteriorly only the occipital polar segment was asymmetrical, with the left side being larger. Dyslexic subjects exhibited asymmetry, with the right side greater than the left side, in contrast to the relatively symmetrical pattern that is normally observed in the midposterior segment that corresponds to the angular gyrus. In the corpus callosum, dyslexic subjects were found to have a larger splenium than nondyslexic subjects, and dyslexic female subjects were found to have a larger splenium than dyslexic male subjects. Because transcallosal pathways connecting the left and right angular gyrus regions traverse through the splenium of the corpus callosum, the above findings in dyslexic subjects suggest an anatomic abnormality in the anaular gyrus region.

Author Affiliations
From the Department of Radiology, University of Miami (Fla) School of Medicine and Mount Sinai Medical Center, Miami Beach, Fla (Drs Duara and Sheldon); the Department of Pediatrics, Genetics Division, Mailman Center for Child Development, University of Miami School of Medicine (Mr Kushch; Drs Gross-Glenn, Rabin, and Lubs; and Ms Jallad); The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center (Drs Duara, Pascal, and Loewenstein and Mr Barker); and the Departments of Psychiatry (Dr Loewenstein) and Neurology (Drs Duara and Levin), University of Miami School of Medicine.

Footnotes
Accepted for publication October 8, 1990.

Reprint requests to The Wien Center for Memory Disorders, Mount Sinai Medical Center, 4300 Alton Rd, Miami Beach, FL 33140 (Dr Duara).

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