Tuberous sclerosis complex in Olmsted County, Minnesota, 1950-1989
C. W. Shepherd, C. M. Beard, M. R. Gomez, L. T. Kurland and J. P. Whisnant
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905.
The incidence of tuberous sclerosis complex in Olmsted County, Minnesota,
was 0.28 per 100,000 person-years from 1950 through 1989, the point
prevalence on December 31, 1989, was 6.9 per 100,000 persons, and the
incidence at birth was 6.0 per 100,000 live births. The incidence was 0.13
per 100,000 person-years from 1950 through 1974 and 0.46 per 100,000
person-years from 1975 through 1989. The higher rate of diagnosis during
the later period is believed to be due to the use of computed tomography.
Of the 12 patients considered in this study, one patient presented with
seizures and severe intellectual disability, six patients presented with
seizures, three patients presented with multiple facial angiofibroma, and
two patients were asymptomatic.
