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Siegfried M. Pueschel, MD, PhD, MPH; Sydney Louis, MD; Pamela McKnight, MD

Arch Neurol. 1991;48(3):318-320.

Abstract
• The prevalence, onset, and type of seizure disorders, as well as seizure control, were studied in a large cohort of 405 individuals with Down syndrome (age range, 6 months to 45 years). The evaluation of a questionnaire completed by the subjects' parents and of the patients' medical records indicated that 33 (8.1%) of 405 persons with Down syndrome had seizure disorder. With regard to the onset of seizures, a bimodal distribution was noted: 40% of patients began having seizures before the age of 1 year, and another 40% started with seizure activity in the third decade of life. In the younger age group, primarily infantile spasms and tonic-clonic seizures with myoclonus were observed, and the older patients often had partial simplex or partial complex seizures as well as tonic-clonic seizures.

Author Affiliations
From the Departments of Pediatrics (Dr Pueschel) and Neurology (Drs Louis and McKnight), Rhode Island Hospital, Providence.

Footnotes
Accepted for publication September 17, 1990.

Reprints not available.

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