Abnormal vitamin B12 metabolism in human immunodeficiency virus infection. Association with neurological dysfunction
K. D. Kieburtz, D. W. Giang, R. B. Schiffer and N. Vakil
Department of Neurology, University of Rochester, School of Medicine, NY 14642.
An increased prevalence of vitamin B12 deficiency has been reported in
patients infected by the human immunodeficiency virus (HIV). We report an
unexpectedly high prevalence (20%) of such abnormal vitamin B12 metabolism
in a population of HIV-infected patients referred for neurological
evaluation. This abnormality was associated with both peripheral neuropathy
and myelopathy. A majority of those treated with cyanocobalamin had a
therapeutic response. Selected neuropathological results suggest a
relationship between vitamin B12 deficiency and vacuolar myelopathy.
Vitamin B12 deficiency may be a frequent and treatable cause of
neurological dysfunction in patients with HIV infection.
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