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Charles A. Nelson, PhD; Paul F. Collins; Fernando Torres, MD

Arch Neurol. 1991;48(2):141-147.

Abstract
• Event-related potentials were recorded over occipital and parietal scalp from 20 patients suffering from intractable partial complex seizures prior to undergoing a temporal lobectomy. Subjects were presented with language and nonlanguage visual stimuli using a divided-field, "oddball" paradigm. Although behavioral performance (button-press accuracy, reaction time, and running counts) was comparable across all groups (although accuracy was worse for those in the left temporal group), patients showed tremendous variability in both the amplitude and latency of the P300 response. Particularly notable was the observation that more slow wave activity was present among the patients than among the control subjects, and those scheduled for a left temporal resection evinced more amplitude reduction than those scheduled for a right temporal resection. In addition, a number of patients appeared not to show a P300 response at all. These results are discussed in the context of the utility of using noninvasive event-related potential measures to examine both memory impairment and the integrity of the neural structures that mediate memory functioning in certain patient populations.

Author Affiliations
From the Center for Research in Learning, Perception, and Cognition (Dr Nelson), the Department of Psychology (Mr Collins), and the Department of Neurology (Dr Torres), University of Minnesota, Minneapolis.

Footnotes
Accepted for publication August 27, 1990.

Presented as a poster exhibit at the Society for Psychophysiological Research, San Francisco, Calif, October 19-23, 1988, and New Orleans, La, October 18-22, 1989.

Reprint requests to Center for Research in Learning, Perception, and Cognition, University of Minnesota, 75 E River Rd, Minneapolis, MN 55455 (Dr Nelson).

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