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Thomas A. Sandson, MD; Kirk R. Daffner, MD; Paulo A. Carvalho, MD; M-Marsel Mesulam, MD

Arch Neurol. 1991;48(12):1300-1303.

Abstract
• We treated a 62-year-old woman who developed a dramatic change in personality and behavior following a discrete left-sided medial thalamic infarction involving the dorsomedial nucleus. Neuropsychological testing demonstrated severe impairment of complex executive behaviors that are usually associated with frontal lobe function. Electroencephalography and single-photon emission computed tomography strongly implicated dysfunction of the ipsilateral frontal lobe. This case further supports a functional and physiologic thalamofrontal linkage as part of a broader cerebral network modulating complex human behavior.

Author Affiliations
From the Behavioral Neurology Unit (Drs Sandson, Daffner, and Mesulam), Beth Israel Hospital, and the Department of Radiology, Brigham and Women's Hospital (Dr Carvalho), Boston, Mass.

Footnotes
Accepted for publication May 15, 1991.

Reprint requests to the Behavioral Neurology Unit, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215 (Dr Sandson).

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