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Incidence and Relationship to Other Nervous System Dysfunction

Colin D. Hall, MBChB; Clyde R. Snyder, MD; John A. Messenheimer, MD; Jean W. Wilkins, PhD; Wendy T. Robertson, MA; Robert A. Whaley, MD; Kevin R. Robertson, PhD

Arch Neurol. 1991;48(12):1273-1274.

Abstract
• A cohort of 94 patients infected with human immunodeficiency virus was evaluated clinically and electrophysiologically for the presence of peripheral neuropathy, and the results were compared with evaluations of central nervous system function. Thirty-two (34%) had some degree of peripheral neuropathy; 18 (19%) (six [12%] of the 49 asymptomatic patients, five [45%] of the 11 patients with acquired immunodeficiency syndrome [AIDS], and seven [21%] of the 34 patients with AIDS-related complex) had neuropathy on clinical examination; and 21 (23%) (eight [16%] asymptomatic, four [36%] AIDS, and nine [26%] AIDS-related complex) had neuropathy on electrophysiologic evaluation. There was a significant correlation between the presence of neuropathy and evidence of central nervous system dysfunction.

Author Affiliations
From the AIDS Neurologic Center (Drs Hall, Snyder, Messenheimer, Wilkins, Robertson, and Whaley and Ms Robertson) and the Departments of Neurology (Drs Hall, Snyder, Messenheimer, Wilkins, and Robertson and Ms Robertson), Radiology (Dr Whaley), and Psychiatry (Drs Wilkins and Robertson), University of North Carolina School of Medicine, Chapel Hill.

Footnotes
Accepted for publication August 1, 1991.

Reprint requests to Department of Neurology, University of North Carolina School of Medicine, CB 7025, Clinical Sciences Building, Chapel Hill, NC 27599-7025 (Dr Hall).

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