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Neurologic Complications of Nonneuronopathic Gaucher's Disease
R. P. Grewal, MD;
S. H. Doppelt, MD;
M. A. Thompson, MD, PhD;
D. Katz, MD;
R. O. Brady, MD;
N. W. Barton, MD, PhD
Arch Neurol. 1991;48(12):1271-1272.
Abstract
• We describe eight patients with type 1 Gaucher's disease who developed neurologic complications that were secondary to systemic features of the illness. Four patients experienced neurologic difficulties because of coagulopathy, and the other four patients had involvement of the nervous system secondary to skeletal disease. Early recognition of these complications in patients with type 1 Gaucher's disease may lead to improved neurologic outcome.
Author Affiliations
From the Developmental and Metabolic Neurology Branch (Drs Grewal, Brady, and Barton) and Office of the Clinical Director (Dr Katz), National Institute of Neurological Disorders and Stroke (NINDS), and Laboratory of Pathology, National Cancer Institute (Dr Thompson), National Institutes of Health, Bethesda, Md; and Department of Orthopedic Surgery, Massachusetts General Hospital, Boston (Dr Doppelt).
Footnotes
Accepted for publication July 2, 1991.
Reprint requests to National Institute of Neurological Disorders and Stroke, Bldg 10, Room 3DO3, National Institutes of Health, Bethesda, MD 20892 (Dr Grewal).
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