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Association With Glasgow Coma Score and Awakening

Peggy S. Gott, PhD; Adrian L. Rabinowicz, MD; Christopher M. DeGiorgio, MD

Arch Neurol. 1991;48(12):1267-1270.

Abstract
• Auditory event-related potentials (ERPs) were performed in 20 patients with nontraumatic coma to determine the presence of a P300 ERP in coma and its association with the Glasgow Coma Score and awakening (Glasgow Outcome Score, 3). A standard "oddball" paradigm was used: frequent tone, 1 kHz; rare tone, 2 kHz and 4 Hz; probability, 20%. The Glasgow Coma Score was determined concurrently with the P300 ERP. Thirty percent (6/20) of the comatose patients had a P300 ERP. The mean Glasgow Coma Score was significantly higher for those with a P300 ERP. Eighty-three percent (5/6) of those with a P300 ERP awoke. Presence of a P300 ERP was associated significantly with awakening, but absence of a P300 ERP did not preclude it.

Author Affiliations
From the EEG/Evoked Potential Laboratory, Los Angeles County and University of Southern California Medical Center, and Department of Neurology, School of Medicine, University of Southern California, Los Angeles.

Footnotes
Accepted for publication July 11, 1991.

Presented in part at the annual meeting of the American Electroencephalographic Society, Houston, Tex, September 24,1990.

Reprint requests to Department of Neurology, General Hospital, Room 5641, University of Southern California School of Medicine, 2025 Zonal Ave, Los Angeles, CA 90033 (Dr Gott).

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