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  Vol. 48 No. 1, January 1991 TABLE OF CONTENTS
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A trial of thiamine in Alzheimer's disease

K. A. Nolan, R. S. Black, K. F. Sheu, J. Langberg and J. P. Blass
Altschul Laboratory for Dementia Research, Cornell University Medical College, Burke Rehabilitation Center, White Plains, NY 10605.

Because a previous short-term study demonstrated a statistically significant, but not clinically important, improvement in cognitive test scores during thiamine treatment in patients with dementia of the Alzheimer's type, a 12-month, double-blind, parallel-group study was conducted to examine whether long-term administration of thiamine at 3 g/d might slow the progression of dementia of the Alzheimer's type. Fifteen subjects were enrolled and 10 completed the 1-year study. Data are available for two additional subjects through the first 9 months of study. No significant differences were found between the placebo and thiamine groups at any point during the study. In both groups, overall means for the Mini-Mental State Examination, verbal learning, and naming scores decreased significantly over the 12-month study period. These results do not support the hypothesis that long-term administration of thiamine at 3 g/d might slow the progression of dementia of the Alzheimer's type.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effectiveness of Nutritional Supplements on Cognitive Functioning in Elderly Persons: A Systematic Review
Manders et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2004;59:M1041-M1049.
ABSTRACT | FULL TEXT  





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