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K. A. Nolan, PhD; R. S. Black, MD; K. F. R. Sheu, PhD; J. Langberg; J. P. Blass, MD, PhD

Arch Neurol. 1991;48(1):81-83.

Abstract
• Because a previous short-term study demonstrated a statistically significant, but not clinically important, improvement in cognitive test scores during thiamine treatment in patients with dementia of the Alzheimer's type, a 12-month, double-blind, parallel-group study was conducted to examine whether long-term administration of thiamine at 3 g/d might slow the progression of dementia of the Alzheimer's type. Fifteen subjects were enrolled and 10 completed the 1-year study. Data are available for two additional subjects through the first 9 months of study. No significant differences were found between the placebo and thiamine groups at any point during the study. In both groups, overall means for the Mini-Mental State Examination, verbal learning, and naming scores decreased significantly over the 12-month study period. These results do not support the hypothesis that long-term administration of thiamine at 3 g/d might slow the progression of dementia of the Alzheimer's type.

Author Affiliations
From the Altschul Laboratory for Dementia Research, Cornell University Medical College at Burke Rehabilitation Center, White Plains, NY.

Footnotes
Accepted for publication August 1, 1990.

Reprint requests to Dementia Research Service, Burke Rehabilitation Center, 785 Mamaroneck Ave, White Plains, NY 10605 (Dr Nolan).

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