This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Janice Shanthi Subramaniam, BSc(Hon); Con Yiannikas, MD, FRACP

Arch Neurol. 1990;47(9):989-994.

Abstract
• We performed median and tibial nerve somatosensory evoked potentials (SEPs), pattern-shift visual evoked potentials (PSVEPs), and brain-stem auditory evoked potentials (BAEPs) on 27 patients with motor neuron disease (MND). Median and tibial nerve SEPs were abnormal in 8 (30%) of 27 and 3 (14%) of 21 patients tested, respectively. Central and peripheral abnormalities were recorded in the absence of spondylosis. As a group, patients with MND and no evidence of cervical spondylosis had normal conduction to Erb's point following median nerve stimulation, but conduction times beyond this point were prolonged. The PSVEPs and BAEPs were within normal limits in all patients, excluding abnormalities attributable to other disease, but the group P100 latency was significantly prolonged in the group with MND. The BAEPs were normal in the group with MND. This study provides neurophysiological evidence of sensory system involvement in MND.

Author Affiliations
From the Department of Clinical Neurophysiology, Westmead Hospital, New South Wales, Australia.

Footnotes
Accepted for publication January 29, 1990.

Reprint requests to Department of Clinical Neurophysiology, Westmead Hospital, Westmead, New South Wales 2145, Australia (Dr Yiannikas).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?