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Jo F. V. Caekebeke, MD; A. C. Boudewyn Peters, MD; Bodvaz Vandvik, MD; Oebele F. Brouwer, MD; Henry M. de Bakker, MD

Arch Neurol. 1990;47(9):1033-1035.

Abstract
• A previously healthy 5-year-old boy developed cerebral vasculopathy, presenting as two episodes of acute hemiparesis 3 and 9 months, respectively, after a primary varicella infection (chickenpox). This association has not been reported before, to our knowledge, although cerebral vasculopathy is a well-known complication of herpes zoster ophthalmicus. The diagnosis was based on the presence of oligoclonal varicella-specific IgG in the cerebrospinal fluid and angiographic findings. Clinical and angiographic follow-up, and serial thymidine kinase activity levels in the cerebrospinal fluid suggested a self-limiting course of the virus-induced vasculopathy. Varicella zoster virus seems to be another potential causative agent to be considered in acute childhood hemiplegia.

Author Affiliations
From the Departments of Neurology, Division of Child Neurology (Drs Caekebeke, Peters, and Brouwer), and Radiology, Division of Neuroradiology (Dr de Bakker), University Hospital, Leiden, the Netherlands, and the Department of Neurology, Ulleväle Sykehus, Oslo, Norway (Dr Vandvik).

Footnotes
Accepted for publication August 2, 1989.

Reprints not available.

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