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Neoplastic Angioendotheliomatosis
Henry G. Raroque, Jr, MD;
Raúl N. Mandler, MD;
Marc S. Griffey, MD;
William W. Orrison, MD;
Mario Kornfeld, MD
Arch Neurol. 1990;47(8):929-930.
Abstract
• A 60-year-old white man presented with aphasia, seizures, paraparesis, and incontinence. His serologic and hematologic profiles were unremarkable. His cerebrospinal fluid showed pleocytosis, increased daily central nervous system IgG synthesis, increased myelin basic protein, and negative cytology and cultures. Cerebral computed tomography exhibited multiple areas of hypodensity but spinal computed tomography and myelography showed no abnormalities. Cranial and spinal magnetic resonance imaging revealed areas of increased signal on T2-weighted images. The use of gadolinium—pentetic acid on T1-weighted images delineated smaller areas of cortical enhancement with surrounding rim of decreased signal. Brain biopsy showed intravascular malignant cells positive for leukocyte common antigen and B-cell markers. The diagnosis was neoplastic angioendotheliomatosis (intravascular lymphomatosis). To our knowledge, this is the first report on the use of both cranial and spinal magnetic resonance imaging in this condition.
Author Affiliations
From the Departments of Neurology (Dr Raroque and Mandler), Radiology (Drs Griffey and Orrison), and Pathology (Dr Kornfeld), University of New Mexico School of Medicine, Albuquerque.
Footnotes
Accepted for publication January 19, 1990.
Reprint requests to Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM 87131 (Dr Mandler).
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