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A. S. Aniskiewicz, PhD; Neva L. Frumkin, PhD; Debbie E. Brady, MS; James B. Moore, MD; Abraham Pera, DO

Arch Neurol. 1990;47(8):911-916.

Abstract
• We studied three patients with schizencephaly and related the results of comprehensive neuropsychologic and speech/language assessments to the severity and location of the brain malformations as appreciated by magnetic resonance imaging. Level of general intellectual functioning related to the amount of brain tissue involved, and variations in specific neurobehavioral abilities reflected the location of the brain malformation and the prenatal onset of the disorder. The overall findings emphasize the importance of comprehensive neuropsychologic and speech/language studies for appreciating the impact of prenatal neural insult on the functional reorganization of the brain and subsequent neurobehavioral functioning.

Author Affiliations
From the Neurobehavioral Science Section, Department of Radiology (Drs Aniskiewicz and Frumkin, and Ms Brady), Radiology (Drs Moore and Pera), and Psychiatry (Dr Aniskiewicz), Michigan State University, East Lansing. Dr. Frumkin is now with the Aphasia Research Center, Veterans Administration Medical Center, Boston, Mass; Ms Brady is now with Columbia (SC) College; and Drs Moore and Pera are now with the Hemet (Calif) Valley Imaging Medical Group.

Footnotes
Accepted for publication November 3, 1989.

Reprint requests to Department of Radiology, B220 Clinical Center, East Lansing, MI 48824-1315 (Dr Aniskiewicz).

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