Are there neuropsychologic manifestations of the gene for Huntington's disease in asymptomatic, at-risk individuals?
M. E. Strauss and J. Brandt
Department of Psychiatry, Johns Hopkins University, Baltimore, Md.
It has recently been reported that persons at risk for Huntington's disease
who test positive for the linked restriction fragment length polymorphism
on chromosome 4 display neuropsychologic impairments when compared with
at-risk subjects who test negative for this marker. We have studied a
substantially larger series of at-risk subjects who have been thoroughly
screened for the absence of neurologic or psychiatric features of
Huntington's disease and have undergone predictive DNA testing. No evidence
of cognitive or emotional differences between marker-positive and
marker-negative individuals was found. Consideration of the designs and
findings of the two studies indicates that it is premature to conclude that
there are neuropsychologic impairments in Huntington's disease that precede
the clinical onset of the illness.
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Longitudinal Cognitive and Motor Changes Among Presymptomatic Huntington Disease Gene Carriers
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Are cognitive changes the first symptoms of Huntington's disease? A study of gene carriers
Hahn-Barma et al.
J. Neurol. Neurosurg. Psychiatry 1998;64:172-177.
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