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Milton E. Strauss, PhD; Jason Brandt, PhD

Arch Neurol. 1990;47(8):905-908.

Abstract
• It has recently been reported that persons at risk for Huntington's disease who test positive for the linked restriction fragment length polymorphism on chromosome 4 display neuropsychologic impairments when compared with at-risk subjects who test negative for this marker. We have studied a substantially larger series of at-risk subjects who have been thoroughly screened for the absence of neurologic or psychiatric features of Huntington's disease and have undergone predictive DNA testing. No evidence of cognitive or emotional differences between markerpositive and marker-negative individuals was found. Consideration of the designs and findings of the two studies indicates that it is premature to conclude that there are neuropsychologic impairments in Huntington's disease that precede the clinical onset of the illness.

Author Affiliations
From the Departments of Psychiatry and Behavioral Sciences (Drs Strauss and Brandt) and Psychology (Dr Strauss), The Johns Hopkins University and School of Medicine, Baltimore, Md. Dr Strauss is now with Case Western Reserve University, Cleveland, Ohio.

Footnotes
Accepted for publication October 11, 1989.

Reprint requests to Department of Psychology, Case Western Reserve University, Cleveland, OH 44106 (Dr Strauss).

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