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Steven J. Huber, PhD; Donald W. Chakeres, MD; George W. Paulson, MD; Rohit Khanna

Arch Neurol. 1990;47(7):735-737.

Abstract
• Magnetic resonance imaging was utilized to examine changes in the pars compacta associated with Parkinson's disease. We found a reduction in average width of the pars compacta in advanced- but not early-stage patients. Conversely, a significant difference in width (right minus left) was observed in early- but not late-stage patients. Width asymmetry may be a sensitive magnetic resonance imaging indicator for the early detection of Parkinson's disease when there is a predominance of unilateral clinical symptoms.

Author Affiliations
From the Departments of Neurology (Drs Huber and Paulson) and Radiology (Dr Chakeres and Mr Khanna), The Ohio State University College of Medicine, Columbus.

Footnotes
Accepted for publication November 29, 1989.

Reprint requests to Department of Neurology, The Ohio State University, Room 425, Means Hall, 1654 Upham Dr, Columbus, OH 43210 (Dr Huber).

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