You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 47 No. 5, May 1990 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 year

C. R. Freed, R. E. Breeze, N. L. Rosenberg, S. A. Schneck, T. H. Wells, J. N. Barrett, S. T. Grafton, S. C. Huang, D. Eidelberg and D. A. Rottenberg
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.

In an effort to improve the clinical signs of Parkinson's disease, we have implanted mesencephalic dopamine cells from a 7-week human embryo into the caudate and putamen of a 52-year-old man with Parkinson's disease. Fetal tissue was obtained from elective abortion. The woman and the patient with Parkinson's disease were unknown to each other. The woman gave specific consent and was not paid. The patient had a 20-year history of parkinsonism treated with multiple drug therapies including levodopa/carbidopa (Sinemet) every 2 1/2 hours. His symptoms were worse on the left side. For 5 months prior to transplantation, the patient underwent clinical evaluations by both a neurologist and a computer system installed in his home for daily measurement of walking and hand movements. Preoperative positron emission tomographic scanning with 6-L[18F]fluorodopa (fluorodopa) demonstrated severe dopamine depletion bilaterally. Fetal tissue was matched to the patient for ABO blood antigens, and maternal serum was screened for hepatitis B and human immunodeficiency virus type 1 prior to surgery. Fetal tissue was implanted stereotactically throughout the caudate and putamen on the right side of the brain via 10 needle tracks. The patient was not immunosuppressed. Results 12 months after surgery showed 42% improvement in left-hand speed before the first morning dose of drug and 40% greater response to drug therapy. Right-hand speed increased 15% before drug therapy and 23% after drug therapy. Reaction time was unaffected. Walking speed increased 33% after drug administration, although walking speed before the first morning dose of drugs declined 40%. Walking speed on an all-day basis improved 17%.(ABSTRACT TRUNCATED AT 250 WORDS)

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Generation of Tyrosine Hydroxylase Positive Neurons from Human Embryonic Stem Cells after Coculture with Cellular Substrates and Exposure to GDNF
Buytaert-Hoefen et al.
Stem Cells 2004;22:669-674.
ABSTRACT | FULL TEXT  

Effects of Perceived Treatment on Quality of Life and Medical Outcomes in a Double-blind Placebo Surgery Trial
McRae et al.
Arch Gen Psychiatry 2004;61:412-420.
ABSTRACT | FULL TEXT  

Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease?
Freed
Proc. Natl. Acad. Sci. USA 2002;99:1755-1757.
FULL TEXT  

Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease
Freed et al.
NEJM 2001;344:710-719.
ABSTRACT | FULL TEXT  

Long-term Evaluation of Bilateral Fetal Nigral Transplantation in Parkinson Disease
Hauser et al.
Arch Neurol 1999;56:179-187.
ABSTRACT | FULL TEXT  

Understanding Parkinson Disease
Cummings
JAMA 1999;281:376-378.
FULL TEXT  

Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells
Clarkson et al.
Proc. Natl. Acad. Sci. USA 1998;95:1265-1270.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1990 American Medical Association. All Rights Reserved.