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  Vol. 47 No. 4, April 1990 TABLE OF CONTENTS
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Regional Cerebral Blood Flow in Patients With Leuko-Araiosis and Atherosclerotic Carotid Artery Disease

Karl Herholz, MD; Walter Heindel, MD; Angelika Rackl, MD; Ines Neubauer, MD; Wolfgang Steinbrich, MD; Uwe Pietrzyk, PhD; Heide Erasmi-Körber, MD; Wolf-Dieter Heiss, MD

Arch Neurol. 1990;47(4):392-396.


Abstract



• The relation between white-matter lesions (WMLs), demonstrated with magnetic resonance imaging, and regional cerebral blood flow (CBF), measured with dynamic positron emission tomography and [18F] fluoromethane, was investigated in 20 patients with atherosclerotic disease of the internal carotid artery. There was no correlation between the extent of small patchy WMLs and hemispheric CBF, but hemispheric CBF was significantly reduced in 5 patients with multiple large or confluent lesions. Distinct focal cortical CBF reductions were observed when large WMLs (>5 mm) were located directly beneath the cortex, whereas large WMLs in deeper white matter were associated with a more diffuse decrease of cortical perfusion. There was no evidence of preferential CBF reduction in vascular border zones with increasing severity of WMLs or stenosis of the internal carotid artery. The side of previous transient ischemic symptoms correlated significantly with hemispheric CBF asymmetries, but not with asymmetries of WMLs and internal carotid artery stenosis. It can be concluded from these results that the presence of small patchy WMLs shown by magnetic resonance imaging cannot be used as evidence of impaired cerebral perfusion, while large lesions indicate clinically relevant cerebrovascular disease affecting cortical blood flow.



Author Affiliations



From the Universitätsklinik für Neurologie and Max-Planck-Institut für neurologische Forschung, Radiologisches Institut and Chirurgische Klinik der Universität zu Köln, West Germany.


Footnotes



Accepted for publication August 9, 1989.

Reprint requests to Universitätsklinik für Neurologie, Joseph-Stelzmann-Strasse 9, D-5000 Köln 41 (Lindenthal), West Germany (Dr Heiss).



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