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Absence of Antibodies to Lentiviruses

Robert P. Friedland, MD; Conrad May, MD; John Dahlberg, PhD

Arch Neurol. 1990;47(2):177-178.

Abstract
• To evaluate the possible role of lentiviruses in Alzheimer's disease we searched for cross-reactive antibodies to human immunodeficiency virus type 1, caprine arthritis encephalitis virus, and equine infectious anemia virus in Alzheimer's disease, Down's syndrome, and related dementing illnesses in serum samples and cerebrospinal fluid samples and in healthy age-matched control subjects. No cross-reactive antibodies were detected.

Author Affiliations
From the Section on Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging (Drs Friedland and May) and Laboratory of Cellular and Molecular Biology, National Cancer Institute (Dr Dahlberg), National Institutes of Health, Bethesda, Md. Dr Dahlberg is now with the Pan-Data Systems Inc, Rockville, Md.

Footnotes
Accepted for publication August 2, 1989.

Reprint requests to Section on Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging, Bldg 10, Room 6C414, National Institutes of Health, Bethesda, MD 20891 (Dr Friedland).

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