This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Nicola Wolfe, PhD; Richard Linn, PhD; Viken L. Babikian, MD; Janice E. Knoefel, MD; Martin L. Albert, MD

Arch Neurol. 1990;47(2):129-132.

Abstract
• To characterize cognitive impairments following multiple subcortical lacunar infarcts (lacunes), we prospectively compared the neuropsychological performance of 11 subjects with multiple lacunes with 11 medical control subjects matched for age and education who had no clinical or computed tomographic evidence of central nervous system disease. Subjects with multiple subcortical lacunes displayed neuropsychological signs of frontal system dysfunction, even though only 27% met the criteria for clinical diagnosis of dementia. They exhibited significant deficits in shifting mental set, response inhibition, and executive function. In addition, they were more often rated apathetic on a behavior-rating scale. We propose a continuum of cognitive impairments in lacunar states, ranging from frontal systems impairment to dementia.

Author Affiliations
From the Department of Neurology, Boston (Mass) University School of Medicine and Boston Veterans Administration Medical Center.

Footnotes
Accepted for publication June 5, 1989.

Reprint requests to Department of Neurology (127), Boston Veterans Administration Medical Center, 150 S Huntington Ave, Boston, MA 02130 (Dr Albert).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Pattern of Cognitive Performance in CADASIL: A Monogenic Condition Leading to Subcortical Ischemic Vascular Dementia
Peters et al.
Am. J. Psychiatry 2005;162:2078-2085.
ABSTRACT | FULL TEXT  

Cerebral small-vessel disease and decline in information processing speed, executive function and memory
Prins et al.
Brain 2005;128:2034-2041.
ABSTRACT | FULL TEXT  

Effects of White Matter Lesions and Lacunes on Cortical Function
Reed et al.
Arch Neurol 2004;61:1545-1550.
ABSTRACT | FULL TEXT  

White matter lesions impair frontal lobe function regardless of their location
Tullberg et al.
Neurology 2004;63:246-253.
ABSTRACT | FULL TEXT  

Cognitive impairment and functional outcome after stroke associated with small vessel disease
Mok et al.
J. Neurol. Neurosurg. Psychiatry 2004;75:560-566.
ABSTRACT | FULL TEXT  

Heterogeneity of Cerebral Blood Flow in Alzheimer Disease and Vascular Dementia
Yoshikawa et al.
Am. J. Neuroradiol. 2003;24:1341-1347.
ABSTRACT | FULL TEXT  

Statistical Image Analysis of Cerebral Blood Flow in Vascular Dementia with Small-Vessel Disease
Yoshikawa et al.
JNM 2003;44:505-511.
ABSTRACT | FULL TEXT  

Executive Control Function: A Review of Its Promise and Challenges for Clinical Research. A Report From the Committee on Research of the American Neuropsychiatric Association
Royall et al.
J. Neuropsychiatry Clin. Neurosi. 2002;14:377-405.
ABSTRACT | FULL TEXT  

Executive dysfunction in subcortical ischaemic vascular disease
Kramer et al.
J. Neurol. Neurosurg. Psychiatry 2002;72:217-220.
ABSTRACT | FULL TEXT  

Stroke Risk Predicts Verbal Fluency Decline in Healthy Older Men: Evidence From the Normative Aging Study
Brady et al.
Journals of Gerontology Series B: Psychological Sciences and Social Science 2001;56:P340-346.
ABSTRACT | FULL TEXT  

Effects of Subcortical Cerebral Infarction on Cortical Glucose Metabolism and Cognitive Function
Kwan et al.
Arch Neurol 1999;56:809-814.
ABSTRACT | FULL TEXT  

Characterization of risk factors for vascular dementia: The Honolulu-Asia Aging Study
Ross et al.
Neurology 1999;53:337-337.
ABSTRACT | FULL TEXT  

Comparative Evolution of Alzheimer Disease, Vascular Dementia, and Mixed Dementia
Bowler et al.
Arch Neurol 1997;54:697-703.
ABSTRACT  

Neuropsychological, Psychiatric, and Cerebral Blood Flow Findings in Vascular Dementia and Alzheimer's Disease
Starkstein et al.
Stroke 1996;27:408-414.
ABSTRACT | FULL TEXT  

Cortical Abnormalities Associated With Subcortical Lesions in Vascular Dementia: Clinical and Positron Emission Tomographic Findings
Sultzer et al.
Arch Neurol 1995;52:773-780.
ABSTRACT  

Prospective CT Confirms Differences Between Vascular and Alzheimer's Dementia
Meyer et al.
Stroke 1995;26:735-742.
ABSTRACT | FULL TEXT  

Neuropsychological Deficits in Vascular Dementia vs Alzheimer's Disease: Frontal Lobe Deficits Prominent in Vascular Dementia
Kertesz and Clydesdale
Arch Neurol 1994;51:1226-1231.
ABSTRACT  

Cognitive Dysfunction Following Subcortical Infarction
Corbett et al.
Arch Neurol 1994;51:999-1007.
ABSTRACT  

Are Multiple Cerebral Infarcts Synergistic?
Wolfe et al.
Arch Neurol 1994;51:211-215.
ABSTRACT  

Failure of CT Scan to Detect Ischemic Lesions in Patients With Dementia
Kurita et al.
J Geriatr Psychiatry Neurol 1993;6:245-250.
ABSTRACT  

ECT-Induced Interictal Delirium in Patients With a History of a CVA
Martin et al.
J Geriatr Psychiatry Neurol 1992;5:149-155.
ABSTRACT  

Neuropsychological Correlates of White-Matter Lesions in Healthy Elderly Subjects: A Threshold Effect
Boone et al.
Arch Neurol 1992;49:549-554.
ABSTRACT  

Hypertension and the Brain
Phillips and Whisnant
Arch Intern Med 1992;152:938-945.
ABSTRACT  

Frontal Lobe Dysfunction Following Infarction of the Left-Sided Medial Thalamus
Sandson et al.
Arch Neurol 1991;48:1300-1303.
ABSTRACT  

Subcortical Structural Changes in ECT-Induced Delirium
Figiel et al.
J Geriatr Psychiatry Neurol 1990;3:172-176.
ABSTRACT